Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50010542
TargetMas-related G-protein coupled receptor member X2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at MRGPX2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sosei Heptares

Curated by ChEMBL
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataIC50: 5.01E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391716(US10300056, Example 1 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50539955(CHEMBL4638938)
Affinity DataKi:  0.0251nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391726(US10300056, Example 11 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0316nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391723(US10300056, Example 8 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0398nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391725(US10300056, Example 10 | N-[(2R)-3-(7-methyl-1H- |...)
Affinity DataKi:  0.0631nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391718(US10300056, Example 3 | N-[(2R)-3-(7-methyl-1H- | ...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM391724(US10300056, Example 9 | 3,5-dibromo-Nalpha-{[4-(2-...)
Affinity DataKi:  0.0794nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
LigandPNGBDBM50539954(CHEMBL4636143)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H]telcagepant from recombinant human CLR/RAMP1 expressed in Sf21 insect cell membranes measured after 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed