BindingDB PrimarySearch_ki

Report error Found 134 Enz. Inhib. hit(s) with all data for entry = 50010775

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

EC50: 12nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

EC50: 9nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

EC50: 23nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human PC3 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale assa...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

EC50: 24nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

EC50: 15nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

EC50: 42nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCaP C4-2 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

EC50: 31nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

EC50: 53nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

EC50: 178nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human LNCAP cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

EC50: 15nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

EC50: 12nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

EC50: 40nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human MDA-MB-415 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesosca...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

EC50: 5nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

EC50: 6nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

EC50: 28nMAssay Description:Inhibition of PI3Kbeta in PTEN-deficient human ZR-75-1 cells assessed as reduction in AKT phosphorylation at Ser473 residue after 2 hrs by mesoscale ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

IC50: 2nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

IC50: 2nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

IC50: 3nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

IC50: 3nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM357385(US10214519, Example 111)

IC50: 3nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50070322(CHEMBL3408248 | US9718800, 3.06b)

IC50: 3nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

IC50: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368625(US10227350, Compound 113 | US10227350, Compound 11...)

IC50: 4nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50541951(CHEMBL4634912)

IC50: 5nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368724(US10227350, Compound 140 | US10227350, Compound 13...)

IC50: 6nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368743(US10227350, Compound 158)

IC50: 7nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368724(US10227350, Compound 140 | US10227350, Compound 13...)

IC50: 9nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368724(US10227350, Compound 140 | US10227350, Compound 13...)

IC50: 9nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368626(US10227350, Compound 142 | US10227350, Compound 14...)

IC50: 9nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368688(US10227350, Compound 104 | US10227350, Compound 10...)

IC50: 9nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368626(US10227350, Compound 142 | US10227350, Compound 14...)

IC50: 10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368688(US10227350, Compound 104 | US10227350, Compound 10...)

IC50: 10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368626(US10227350, Compound 142 | US10227350, Compound 14...)

IC50: 10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368688(US10227350, Compound 104 | US10227350, Compound 10...)

IC50: 10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368741(US10227350, Compound 156)

IC50: 12nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM357385(US10214519, Example 111)

IC50: 12nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368674(US10227350, Compound 91)

IC50: 19nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50059637(GSK-2636771 | GSK2636771 | US10660898, Example 31)

IC50: 25nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368624(US10227350, Compound 43)

IC50: 30nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368741(US10227350, Compound 156)

IC50: 35nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50070322(CHEMBL3408248 | US9718800, 3.06b)

IC50: 36nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

IC50: 42nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368657(US10227350, Compound 106 | US10227350, Compound 10...)

IC50: 43nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368658(US10227350, Compound 76)

IC50: 50nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368743(US10227350, Compound 158)

IC50: 52nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368741(US10227350, Compound 156)

IC50: 55nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM357385(US10214519, Example 111)

IC50: 60nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368740(US10227350, Compound 155)

IC50: 62nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM50447094(CHEMBL1972466)

IC50: 63nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
CHEMBL PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Gilead Sciences

Curated by ChEMBL

PNG

BDBM368743(US10227350, Compound 158)

IC50: 75nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

PC cid PC sid Similars

Date in BDB:
8/13/2021
Entry Details Article
PubMed

Displayed 1 to 50 (of 134 total ) | Next | Last >>

Filter my 134 hits

Targets 8▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 30
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 30
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 30
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 20
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 15
- Cytochrome P450 3A4 5
- Cytochrome P450 4B1 2
- Potassium voltage-gated channel subfamily H member 2 2
Publications 1▿
- ACS Med Chem Lett 11: 1236-1243 (2020) 134
Institutions 1▿
- Gilead Sciences 134
Affinity: 2 to 2.5E+4 nM▿
- IC50 119
- EC50 15
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 4