Compile Data Set for Download or QSAR
Report error Found 46 Enz. Inhib. hit(s) with all data for entry = 50012745
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372703(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrol...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372742(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperi...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559903(CHEMBL4760131 | US20160046618, Example 40)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372719(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(azetidine-1-car...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372784(5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372719(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(azetidine-1-car...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372817(6-((Z)-2-(3-((1R,5S,6S)-3-amino-5-methyl-1-(methyl...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372806((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372702((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372702((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372806((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372784(5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372703(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrol...)
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559903(CHEMBL4760131 | US20160046618, Example 40)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372822(6-((Z)-2-(3-((1S,5S,6S)-1-acetyl-3-amino-5-methyl-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559903(CHEMBL4760131 | US20160046618, Example 40)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372817(6-((Z)-2-(3-((1R,5S,6S)-3-amino-5-methyl-1-(methyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372742(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperi...)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372822(6-((Z)-2-(3-((1S,5S,6S)-1-acetyl-3-amino-5-methyl-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372702((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372719(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(azetidine-1-car...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372887(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372696((1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372887(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372817(6-((Z)-2-(3-((1R,5S,6S)-3-amino-5-methyl-1-(methyl...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372696((1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 42nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372742(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(piperi...)
Affinity DataIC50: 45nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372703(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(pyrrol...)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372806((1S,5S,6S)-3-amino-5-(5-((Z)-2-(5-cyanopyridin-2-y...)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372784(5-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 118nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372822(6-((Z)-2-(3-((1S,5S,6S)-1-acetyl-3-amino-5-methyl-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372696((1S,5S,6S)-5-(5-((Z)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372887(6-((Z)-2-(3-((1S,5S,6S)-3-amino-1-(methoxymethyl)-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372697((1S,5S,6S)-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 281nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372697((1S,5S,6S)-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 303nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 940nMAssay Description:Inhibition of recombinant human BACE1 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant human BACE2 using fluorescence substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372697((1S,5S,6S)-5-(5-((E)-2-(5-chloropyridin-2-yl)-2-fl...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50559904(CHEMBL4788256)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of BACE1 in human HEK293 cells transfected with human wild type APP assessed as reduction in Abeta40 production incubated for overnight by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCathepsin E(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 3.92E+5nMAssay Description:Inhibition of CatE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetCathepsin D(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM372720(6-((Z)-2-(3-((1S,5S,6S)-3-amino-5-methyl-1-(morpho...)
Affinity DataIC50: 5.35E+5nMAssay Description:Inhibition of CatD (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed