Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50011872
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50157304(3',5-diallylbiphenyl-2,4'-diol | CHEMBL16901 | cid...)
Affinity DataKd:  2.89E+5nMAssay Description:Binding affinity to human platelet lysate GP6 at 100 uM by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataKd:  1.70E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50049186(CHEMBL1069 | (S)-3-Methyl-2-{pentanoyl-[2'-(1H-tet...)
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50241364(4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-te...)
Affinity DataKd:  3.00E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552059(CHEMBL1532826)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552058(CHEMBL4745006)
Affinity DataKd:  3.60E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50533338(CHEMBL3092388)
Affinity DataKd:  1.50E+6nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552057(CHEMBL4752710)
Affinity DataKd:  8.00E+4nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552056(CHEMBL4797073)
Affinity DataKd:  5.20E+4nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552055(CHEMBL4751401)
Affinity DataKd:  8.50E+5nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552054(CHEMBL4761944)
Affinity DataKd:  5.70E+4nMAssay Description:Binding affinity to recombinant GP6 (unknown origin) at protein to compound ratio of 1 : 1 to 1 : 10 by 2D 15N-1H TROSY-HSQC NMR spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataKd:  41nMAssay Description:Binding affinity to human platelet lysate GP6 at 0.1 uM by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50157304(3',5-diallylbiphenyl-2,4'-diol | CHEMBL16901 | cid...)
Affinity DataKd:  2.89E+5nMAssay Description:Binding affinity to human platelet lysate GP6 at 10 uM by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552053(Glaucocalyxin A)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 10 mins followed by collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552053(Glaucocalyxin A)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 10 mins followed by coll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50: 31nMAssay Description:Modulation of GP6 in human platelets assessed as reduction in convulxin-induced platelet aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50: 48nMAssay Description:Modulation of GP6 in human platelets assessed as reduction in convulxin-induced P-selectin expression preincubated for 20 mins followed by convulxin ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 120nMAssay Description:Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataIC50: 510nMAssay Description:Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)
Affinity DataIC50: 570nMAssay Description:Modulation of GP6 in human platelets reduction in collagen-induced platelet aggregation preincubated for 20 mins followed by collagen stimulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM194087(US9199997, 9 | US9879013, 19(2) | US20230364079, E...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US9758524, Example 6 | U...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Mouse)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50552060(CHEMBL228043 | LFM-A13)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse BTK expressed in baculovirus infected Sf21 cells incubated for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 60 secs followed by collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataIC50: 4.00E+3nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 60 secs followed by coll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM291522(US9580449, Example A39 | 1-(4-(((6-amino-5-(4-phen...)
Affinity DataIC50: 5.84E+3nMAssay Description:Inhibition of GP6 in human whole blood assessed as protein-mediated platelet aggregation preincubated for 15 mins followed by collagen stimulation an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM82258(NSC_3961 | CAS_114798-26-4 | Losartan)
Affinity DataIC50: 2.00E+4nMAssay Description:Modulation of TxA2 receptor in human platelets assessed as reduction in U46619-induced platelet aggregation preincubated for 5 min followed by U46619...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50016900(CINANSERIN | CHEMBL18786 | N-(2-(3-(dimethylamino)...)
Affinity DataIC50: 3.50E+4nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in CRP-induced platelet-aggregation preincubated for 60 secs followed by collagen ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed
TargetPlatelet glycoprotein VI(Human)
University of Leeds

Curated by ChEMBL
LigandPNGBDBM50016900(CINANSERIN | CHEMBL18786 | N-(2-(3-(dimethylamino)...)
Affinity DataIC50: 4.00E+4nMAssay Description:Antagonist activity at GP6 in human platelet assessed as reduction in collagen-induced platelet-aggregation preincubated for 60 secs followed by coll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed