Compile Data Set for Download or QSAR
Report error Found 26 Enz. Inhib. hit(s) with all data for entry = 50011293
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type human ABL Q252H mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type human ABL Y253F mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type human ABL M351T mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of wild type human ABL H396P mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of wild type human ABL using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of wild type human BTK C481S mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged TRKA (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM499811(US11020398, Compound I-123 | US20230364079, Exampl...)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of wild type human BTK using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal His6-tagged TRKA (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human ALK L1196M mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP assay by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50322535(3-[2-(Imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-meth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type human ABL T315I mutant using [EAIYAAPFAKKK] as substrate in presence of gamma33P-ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G595R mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of wild type BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546200(Vecabrutinib | Sns-062 | BIIB-062 | BSK-4841 | FP-...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of BTK C481S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human ALK G1202R mutant using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma-33P]-ATP assay by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546201(CHEMBL4754443)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546203(CHEMBL4761560)
Affinity DataIC50: 9.80nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G667C mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 28nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 41nMAssay Description:Inhibition of EML4/ALK L1196M mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50: 46nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G667C mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM374727(US10246466, Example 93 | (7S,13R)-11-fluoro-7,13-d...)
Affinity DataIC50: 64nMAssay Description:Inhibition of EML4/ALK G1202R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by Cell Tite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50546202(CHEMBL3892335)
Affinity DataIC50: 69nMAssay Description:Inhibition of N-terminal His6-tagged TRKA G595R mutant (unknown origin) (486 to 786 residues) expressed in Escherichia coli using poly-EAY substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 184nMAssay Description:Inhibition of EML4/ALK G1202R mutant (unknown origin) expressed in mouse Ba/F3 cells assessed as antiproliferative activity after 72 hrs by CellTiter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BCR-ABL T315I mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTK C481S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed