Compile Data Set for Download or QSAR
Report error Found 99 Enz. Inhib. hit(s) with all data for entry = 50011193
LigandChemical structure of BindingDB Monomer ID 371616BDBM371616(US10239869, Example 40 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545552BDBM50545552(CHEMBL4646742)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545560BDBM50545560(CHEMBL4634421)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545563BDBM50545563(CHEMBL4636838)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545558BDBM50545558(CHEMBL4642748)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371523BDBM371523((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545567BDBM50545567(CHEMBL4649638)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371635BDBM371635(US10239869, Example 60 | (R)-4-(2-(1H-1,2,3-Triazo...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371776BDBM371776((R)-4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371648BDBM371648((R)-N-(6-Fluoropyridin-2-yl)-4-(2-(2-methyloxazol-...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545554BDBM50545554(CHEMBL4635247)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371652BDBM371652((R)-4-(2-(2-methyloxazol-4-yl)-4-(trifluoromethyl)...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371770BDBM371770((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545556BDBM50545556(CHEMBL4639228)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371697BDBM371697(N-(6-fluoropyridin-2-yl)-4-(2-morpholino-4-(triflu...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371768BDBM371768((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371614BDBM371614(US10239869, Example 38 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371695BDBM371695(4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(pyri...)
Affinity DataIC50: 3nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371584BDBM371584(US10239869, Example 10 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545561BDBM50545561(CHEMBL4641467)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545566BDBM50545566(CHEMBL4642855)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371540BDBM371540((R)-N-(4-Fluoropyridin-2-yl)-4-(2-(1-methyl-1H-pyr...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371780BDBM371780(N-(6-fluoropyridin-2-yl)-4-(2-(6-methylpyridin-3-y...)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545568BDBM50545568(CHEMBL4632456)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545570BDBM50545570(CHEMBL4633186)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371693BDBM371693((R)-4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545564BDBM50545564(CHEMBL4639688)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371777BDBM371777(N-(5-fluoropyrimidin-2-yl)-4-(2-(6-methylpyridin-3...)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371778BDBM371778(4-(2-(6-methylpyridin-3-yl)-4-(trifluoromethyl)phe...)
Affinity DataIC50: 8.70nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545569BDBM50545569(CHEMBL4637997)
Affinity DataIC50: 10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371694BDBM371694(N-(5-fluoropyrimidin-2-yl)-4-(2-morpholino-4-(trif...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371772BDBM371772((R)-4-(2-(5-fluoropyridin-2-yl)-4-(trifluoromethyl...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545559BDBM50545559(CHEMBL4642271)
Affinity DataIC50: 15nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371811BDBM371811(4-(2-(1,1-dioxidothiomorpholino)-4-(trifluoromethy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371612BDBM371612(US10239869, Example 36 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371590BDBM371590(US10239869, Example 16 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371590BDBM371590(US10239869, Example 16 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 18nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371580BDBM371580(US10239869, Example 6 | (R)-N-(5-Fluoropyridin-2-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371612BDBM371612(US10239869, Example 36 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 21nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371582BDBM371582(US10239869, Example 8 | (R)-N-(5-Fluoropyrimidin-2...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371646BDBM371646((R)-N-(5-Fluoropyrimidin-2-yl)-4-(2-(2-methyloxazo...)
Affinity DataIC50: 26nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371620BDBM371620(US10239869, Example 44 | (R)-4-(4'-Fluoro-5-(trifl...)
Affinity DataIC50: 30nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371590BDBM371590(US10239869, Example 16 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 30nMAssay Description:Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545569BDBM50545569(CHEMBL4637997)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371590BDBM371590(US10239869, Example 16 | (R)-4-(2-(1-Methyl-1H-pyr...)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545569BDBM50545569(CHEMBL4637997)
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545569BDBM50545569(CHEMBL4637997)
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371612BDBM371612(US10239869, Example 36 | (R)-4-(2-(6-Fluoropyridin...)
Affinity DataIC50: 34nMAssay Description:Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 371693BDBM371693((R)-4-(2-morpholino-4-(trifluoromethyl)phenyl)-N-(...)
Affinity DataIC50: 35nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50545565BDBM50545565(CHEMBL4641628)
Affinity DataIC50: 36nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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