Compile Data Set for Download or QSAR
Report error Found 27 Enz. Inhib. hit(s) with all data for entry = 50010526
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539761(CHEMBL4648852)
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539762(CHEMBL4632935)
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539765(CHEMBL4640636)
Affinity DataIC50: 3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539760(CHEMBL4636611)
Affinity DataIC50: 4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50: 5nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation incubated for 24 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539759(CHEMBL4646899)
Affinity DataIC50: 6nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539766(CHEMBL4645376)
Affinity DataIC50: 9nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539754(CHEMBL4648671)
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539753(CHEMBL4648056)
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539757(CHEMBL4648124)
Affinity DataIC50: 22nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539758(CHEMBL4640234)
Affinity DataIC50: 64nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50507447(CHEMBL4456598)
Affinity DataIC50: 142nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539747(CHEMBL4645768)
Affinity DataIC50: 254nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539746(CHEMBL4642659)
Affinity DataIC50: 351nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539755(CHEMBL4649703)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539744(CHEMBL4637314)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539745(CHEMBL4642347)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539743(CHEMBL4637434)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539756(CHEMBL4639210)
Affinity DataIC50: 3.32E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539748(CHEMBL4647242)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539750(CHEMBL4649174)
Affinity DataIC50: 4.53E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539749(CHEMBL4643600)
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539752(CHEMBL4638484)
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539751(CHEMBL4649393)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539764(CHEMBL4635454)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed