Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50010583
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477604BDBM477604(US10889564, Example 34 | (R) N-(1-(2-methylphenyl)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477604BDBM477604(US10889564, Example 34 | (R) N-(1-(2-methylphenyl)...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477616BDBM477616(US10889564, Example 46 | (R) N-(1-(2-fluorophenyl)...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477601BDBM477601(US10889564, Example 31 | N-[1-(2,3-dimethylphenyl)...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477601BDBM477601(US10889564, Example 31 | N-[1-(2,3-dimethylphenyl)...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477599BDBM477599(US10889564, Example 29 | N-[1-(2-methylphenyl)-4,5...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477599BDBM477599(US10889564, Example 29 | N-[1-(2-methylphenyl)-4,5...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477616BDBM477616(US10889564, Example 46 | (R) N-(1-(2-fluorophenyl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477618BDBM477618(US10889564, Example 48 | (R) N-(1-(2-fluorophenyl)...)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477586BDBM477586(US10889564, Example 16 | N-[(4R)-1-(2-methylphenyl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477583BDBM477583(US10889564, Example 13 | N-[(4R)-1-(2-fluorophenyl...)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477584BDBM477584(US10889564, Example 14 | N-[(4R)-1-(2-fluorophenyl...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477619BDBM477619(US10889564, Example 49 | (R) N-(1-(2-fluoro-5-meth...)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477600BDBM477600(US10889564, Example 30 | N-[1-(3-methylphenyl)-4,5...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477609BDBM477609(US10889564, Example 39 | N-[(4R)-1-(2-fluorophenyl...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477595BDBM477595(US10889564, Example 25 | 4-methyl-N-[(4R)-1-(2-met...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477592BDBM477592(US10889564, Example 22 | N-(1-phenyl-4,5,6,7-tetra...)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477614BDBM477614(US10889564, Example 44 | N-[(4R)-1-(2-fluorophenyl...)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477621BDBM477621(US10889564, Example 51 | N-[(4R)-1-(2-fluoro-5-met...)
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477607BDBM477607(US10889564, Example 37 | 4-bromo-N-[(4R)-1-(2-fluo...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477606BDBM477606(US10889564, Example 36 | 4-chloro-N-[(4R)-1-(2-flu...)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477602BDBM477602(US10889564, Example 32 | Ethyl 3-[4-(4,5,6,7-tetra...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477617BDBM477617(US10889564, Example 47 | 4-fluoro-N-[(4R)-1-(2-flu...)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477579BDBM477579(US10889564, Example 8 | N-(1-(2-fluorophenyl)-4,5,...)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477612BDBM477612(US10889564, Example 42 | (R) N-(1-(2-fluorophenyl)...)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477620BDBM477620(US10889564, Example 50 | N-[(4R)-1-(2-fluoro-5-met...)
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477611BDBM477611(US10889564, Example 41 | N-[(4R)-1-(2-fluorophenyl...)
Affinity DataIC50: 55nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477597BDBM477597(US10889564, Example 27 | N-(1-phenyl-4,5,6,7-tetra...)
Affinity DataIC50: 95nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477574BDBM477574(US10889564, Example 3 | (R) N-(1-(2-fluorophenyl)-...)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477572BDBM477572(US10889564, Example 1 | N-(1-(2-Fluorophenyl)-4,5,...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540324BDBM50540324(CHEMBL4644245)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540322BDBM50540322(CHEMBL4639767)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477573BDBM477573(US10889564, Example 2 | (S) N-(1-(2-Fluorophenyl)-...)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540326BDBM50540326(CHEMBL4639419)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540325BDBM50540325(CHEMBL4633148)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50540323BDBM50540323(CHEMBL4648021)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Karolinska Institutet

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 477578BDBM477578(US10889564, Example 7 | Methyl 6-({[1-(2-fluorophe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed