Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50010810
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataEC50:  1.10E+6nMAssay Description:Modulating activity at PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 8.90nMAssay Description:Negative allosteric modulation of rat mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 9nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542313(CHEMBL4637618)
Affinity DataIC50: 10nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542315(CHEMBL4642428)
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542315(CHEMBL4642428)
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542305(CHEMBL4640203)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542314(CHEMBL4642338)
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212926(US9278960, 3-45 | US9663506, Example 3-45)
Affinity DataIC50: 16nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542299(CHEMBL4644424)
Affinity DataIC50: 19nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 20nMAssay Description:Negative allosteric modulation of human mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212874(US9278960, 2-21 | US9663506, Example 2-21)
Affinity DataIC50: 21nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542306(CHEMBL4647980)
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542300(CHEMBL4640529)
Affinity DataIC50: 36nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212897(US9278960, 3-16 | US9663506, Example 3-16)
Affinity DataIC50: 36nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Rat)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 54nMAssay Description:Negative allosteric modulation of rat mGluR2 by GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212890(US9278960, 2-37 | US9663506, Example 2-37)
Affinity DataIC50: 58nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212941(US9278960, 4-25 | US9663506, Example 4-25)
Affinity DataIC50: 61nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542301(CHEMBL4638570)
Affinity DataIC50: 68nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212933(US9278960, 4-1 | US9663506, Example 4-1)
Affinity DataIC50: 68nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542316(CHEMBL4635528)
Affinity DataIC50: 91nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542308(CHEMBL4643527)
Affinity DataIC50: 144nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212853(US9278960, 1-24 | US9663506, Example 1-24)
Affinity DataIC50: 149nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542311(CHEMBL4634754)
Affinity DataIC50: 238nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542320(CHEMBL4636186)
Affinity DataIC50: 367nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542318(CHEMBL4634600)
Affinity DataIC50: 404nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542302(CHEMBL4642255)
Affinity DataIC50: 409nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542321(CHEMBL4634351)
Affinity DataIC50: 1.38E+3nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542307(CHEMBL4646222)
Affinity DataIC50: 2.70E+3nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212926(US9278960, 3-45 | US9663506, Example 3-45)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542305(CHEMBL4640203)
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 9.22E+3nMAssay Description:Antagonist activity at mGluR6 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542298(CHEMBL4649821)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR7 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR4 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR3 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at mGluR1 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542309(CHEMBL4646658)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542310(CHEMBL4640683)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542312(CHEMBL4632721)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212874(US9278960, 2-21 | US9663506, Example 2-21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212890(US9278960, 2-37 | US9663506, Example 2-37)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542319(CHEMBL4635360)
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542316(CHEMBL4635528)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212933(US9278960, 4-1 | US9663506, Example 4-1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212941(US9278960, 4-25 | US9663506, Example 4-25)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM212853(US9278960, 1-24 | US9663506, Example 1-24)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50542315(CHEMBL4642428)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human mGluR3 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
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