Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50010808
TargetKelch-like ECH-associated protein 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50109398(CHEMBL2381968)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50434287(CHEMBL2386346)
Affinity DataIC50: 18nMAssay Description:Inhibition of MDM2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542269(CHEMBL4632870)
Affinity DataIC50: 39nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50: 45nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542268(CHEMBL4635216)
Affinity DataIC50: 65nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50459944(CHEMBL4225537)
Affinity DataIC50: 88nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50229787(CHEMBL191334 | 4-((4S,5R)-4,5-bis(4-chlorophenyl)-...)
Affinity DataIC50: 88nMAssay Description:Inhibition of MDM2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441342(CHEMBL2431765 | US9394263, 29)
Affinity DataIC50: 101nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50099062(CHEMBL3344081 | US10730870, Example 3 | US11512083...)
Affinity DataIC50: 185nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441347(CHEMBL2431760 | US9611224, Example 29)
Affinity DataIC50: 194nMAssay Description:Inhibition of XIAP-BIR2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50014097(CHEMBL3260851)
Affinity DataIC50: 670nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542274(CHEMBL4159561)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542273(CHEMBL4159153)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 (unknown origin) by SRP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542269(CHEMBL4632870)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50446138(CHEMBL3108881)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542268(CHEMBL4635216)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441342(CHEMBL2431765 | US9394263, 29)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441347(CHEMBL2431760 | US9611224, Example 29)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of XIAP-BIR3 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542272(CHEMBL4639001)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of VHL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542271(CHEMBL4639742)
Affinity DataKi:  0.900nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50542270(CHEMBL4644415)
Affinity DataKi:  3nMAssay Description:Inhibition of MDM2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50441806(CHEMBL2436226 | US9422331, 32)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed