Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50011150
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545284(CHEMBL4648271)
Affinity DataIC50: 4nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545281(CHEMBL4635100)
Affinity DataIC50: 4nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545277(CHEMBL4643111)
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545278(CHEMBL2441563)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545281(CHEMBL4635100)
Affinity DataIC50: 7nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545284(CHEMBL4648271)
Affinity DataIC50: 8nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545278(CHEMBL2441563)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545277(CHEMBL4643111)
Affinity DataIC50: 12nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545278(CHEMBL2441563)
Affinity DataIC50: 12nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 13nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 22nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 25nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545277(CHEMBL4643111)
Affinity DataIC50: 45nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 62nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545289(CHEMBL4636996)
Affinity DataIC50: 80nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545280(CHEMBL4642158)
Affinity DataIC50: 116nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545283(CHEMBL4634499)
Affinity DataIC50: 120nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545281(CHEMBL4635100)
Affinity DataIC50: 121nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50442173(CHEMBL2441567)
Affinity DataIC50: 126nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545284(CHEMBL4648271)
Affinity DataIC50: 163nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545279(CHEMBL4648924)
Affinity DataIC50: 179nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 281nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 369nMAssay Description:Inhibition of HER2 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 40 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545292(CHEMBL4634817)
Affinity DataIC50: 446nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545282(CHEMBL4634127)
Affinity DataIC50: 569nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545291(CHEMBL4643903)
Affinity DataIC50: 578nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545290(CHEMBL4638194)
Affinity DataIC50: 844nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545286(CHEMBL4639556)
Affinity DataIC50: 4.87E+3nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545287(CHEMBL4641942)
Affinity DataIC50: 4.87E+3nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545288(CHEMBL4646638)
Affinity DataIC50: 5.83E+3nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Jiangsu Aosaikang Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50545285(CHEMBL4632500)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR in human KB cells assessed as reduction in EGF-stimulated EGFR phosphorylation preincubated for 1 hr followed by EGF stimulation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed