Compile Data Set for Download or QSAR
Report error Found 36 Enz. Inhib. hit(s) with all data for entry = 50018727
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611950(CHEMBL5280689)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50353386(US8592410, 88 | CHEMBL1829763 | US8598163, 61 | US...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 22 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611950(CHEMBL5280689)
Affinity DataIC50: 1nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetHydroxysteroid 11-beta dehydrogenase 1(Rhesus macaque)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of monkey 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611953(CHEMBL5289716)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of mouse 11beta-HSD1 in liver microsome incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611951(CHEMBL5289930)
Affinity DataIC50: 3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in 3T3-L1 cells incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM107664(US8575157, 48)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611951(CHEMBL5289930)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM107590(US8575157, 31)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 22 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50: 8nMAssay Description:Inhibition of mouse 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50: 8nMAssay Description:Inhibition of rat 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611946(HSD-016 | Hsd-016)
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50309934(2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-ben...)
Affinity DataIC50: 31nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611947(CHEMBL5287091)
Affinity DataIC50: 55nMAssay Description:Inhibition of human 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM32530(arylsulfonylpiperazine, 2)
Affinity DataIC50: 61nMAssay Description:Inhibition of human 11beta-HSD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611948(CHEMBL5270906)
Affinity DataIC50: 63nMAssay Description:Inhibition of human 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 96nMAssay Description:Inhibition of mouse 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611945(CHEMBL5273329)
Affinity DataIC50: 100nMAssay Description:Inhibition of rat 11beta-HSD1 expressed in Leydig cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50353425(CHEMBL1829740)
Affinity DataIC50: 166nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 22 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50309934(2-(3-Benzoyl-4-hydroxy-1,1-dioxo-1H-1lambda*6*-ben...)
Affinity DataIC50: 210nMAssay Description:Inhibition of mouse 11beta-HSD1 incubated for 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50247012(3beta-O-Succinyl-18-beta-glycyrrhetinic acid | Car...)
Affinity DataIC50: 330nMAssay Description:Inhibition of human 11beta-HSD1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611949(CHEMBL5267006)
Affinity DataIC50: 335nMAssay Description:Inhibition of human 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50233538(3beta-hydroxy-11-oxoolean-12-en-30-oic acid | glyc...)
Affinity DataIC50: 779nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611952(CHEMBL5271419)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611943(18alpha-GLYCYRRHETINIC ACID)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611943(18alpha-GLYCYRRHETINIC ACID)
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells measured after 10 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50117900(CHEMBL463978 | CHEMBL553071 | 3-Chloro-2-methyl-N-...)
Affinity DataIC50: 3.34E+3nMAssay Description:Inhibition of human 11beta-HSD1 using steroid as substrate incubated for 20 to 30 mins by microplate fluorimeter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 5.79E+3nMAssay Description:Inhibition of rat 11beta-HSD1 expressed in Leydig cells incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50611944(CHEMBL5272509)
Affinity DataIC50: 9.07E+3nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 30 mins by HPLC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of human 11beta-HSD2 incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of human 11beta-HSD2 incubated for 2 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 3.52E+4nMAssay Description:Inhibition of rat 11beta-HSD1 in kidney microsomes incubated for 20 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Hong Kong Baptist University

Curated by ChEMBL
LigandPNGBDBM50070942((-)-Epigallocatechin-3-o-gallate | (-)-Epigallocat...)
Affinity DataIC50: 5.80E+4nMAssay Description:Inhibition of human 11beta-HSD1 incubated for 2 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed