Compile Data Set for Download or QSAR
Report error Found 31 Enz. Inhib. hit(s) with all data for entry = 50007462
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM153128(US8993631, 36)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130359(US8822534, Example 5-39 | US8993631, 5-8)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509659(CHEMBL4443138)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130365(US8822534, Example 12-1 | US8822534, Example 11-1 ...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509652(CHEMBL4557208)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509666(CHEMBL4442804)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130355(US8822534, Example 5-7 | US8993631, 5-3)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509647(CHEMBL4518426)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50034842((2R,4S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamin...)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM130354(US8822534, Example 5-4 | US8993631, 5-2)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509655(CHEMBL4466321)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509649(CHEMBL4474653)
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509648(CHEMBL4439270)
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509650(CHEMBL4592467)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509660(CHEMBL4434901)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM7494(US8822534, Example 5-1 | US8822534, 5-36 | US89936...)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509656(CHEMBL4568947)
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509662(CHEMBL4475874)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509658(CHEMBL4459630)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509653(CHEMBL4518025)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509663(CHEMBL4547205)
Affinity DataIC50: 111nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509667(CHEMBL4443565)
Affinity DataIC50: 212nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509654(CHEMBL4448802)
Affinity DataIC50: 275nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509661(CHEMBL4564942)
Affinity DataIC50: 413nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50034864((S)-5-Biphenyl-4-yl-4-(3-carboxy-propionylamino)-p...)
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509646(CHEMBL4471166)
Affinity DataIC50: 792nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509651(CHEMBL4559586)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509645(CHEMBL4465277)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509665(CHEMBL4458213)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509657(CHEMBL4548017)
Affinity DataIC50: 4.18E+3nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNeprilysin(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50509664(CHEMBL4550194)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed