Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50007452
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279989(US10028961, Compound 142 | US10172864, Compound 14...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279977(US10028961, Compound 130 | US10172864, Compound 13...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279960(US10028961, Compound 113 | US10172864, Compound 11...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279996(US10028961, Compound 149 | US10172864, Compound 14...)
Affinity DataIC50: 1nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279884(US10028961, Compound 31 | US10172864, Compound 31 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279855(US10028961, Compound 2 | US10172864, Compound 2 | ...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279996(US10028961, Compound 149 | US10172864, Compound 14...)
Affinity DataIC50: 3nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279898(US10028961, Compound 45 | US10172864, Compound 45 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279957(US10028961, Compound 110 | US10172864, Compound 11...)
Affinity DataIC50: 4nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279894(US10028961, Compound 41 | US10172864, Compound 41 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279960(US10028961, Compound 113 | US10172864, Compound 11...)
Affinity DataIC50: 6nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279989(US10028961, Compound 142 | US10172864, Compound 14...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM280059(US10028961, Compound 212 | US10172864, Compound 21...)
Affinity DataIC50: 7nMAssay Description:Inhibition of IDH1 R132H mutant in glioma patient-derived human TS603 neurosphere cells assessed as reduction in 2-HG content using alpha-ketoglutara...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279977(US10028961, Compound 130 | US10172864, Compound 13...)
Affinity DataIC50: 8nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50503251(AG-221 | Ag 221 | CC-90007 Free Base | Enasidenib ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279894(US10028961, Compound 41 | US10172864, Compound 41 ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279884(US10028961, Compound 31 | US10172864, Compound 31 ...)
Affinity DataIC50: 9nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279854(US10028961, Compound 1 | US10172864, Compound 1 | ...)
Affinity DataIC50: 13nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279957(US10028961, Compound 110 | US10172864, Compound 11...)
Affinity DataIC50: 14nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279855(US10028961, Compound 2 | US10172864, Compound 2 | ...)
Affinity DataIC50: 14nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279996(US10028961, Compound 149 | US10172864, Compound 14...)
Affinity DataIC50: 16nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50509551(CHEMBL4448857)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279855(US10028961, Compound 2 | US10172864, Compound 2 | ...)
Affinity DataIC50: 22nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279854(US10028961, Compound 1 | US10172864, Compound 1 | ...)
Affinity DataIC50: 22nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM280059(US10028961, Compound 212 | US10172864, Compound 21...)
Affinity DataIC50: 22nMAssay Description:Inhibition of IDH2 R140Q mutant (unknown origin) transfected using lentiviral expression system in human U87MG cells assessed as reduction in 2-HG co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279857(US10028961, Compound 4 | BDBM279926 | US10172864, ...)
Affinity DataIC50: 46nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279855(US10028961, Compound 2 | US10172864, Compound 2 | ...)
Affinity DataIC50: 48nMAssay Description:Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50509551(CHEMBL4448857)
Affinity DataIC50: 78nMAssay Description:Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP], mitochondrial(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM279894(US10028961, Compound 41 | US10172864, Compound 41 ...)
Affinity DataIC50: 92nMAssay Description:Inhibition of full-length C-terminal His6 tagged IDH2 R140Q mutant (1 to 452 residues) (unknown origin) homodimer expressed in Sf9 cells assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Agios Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50503251(AG-221 | Ag 221 | CC-90007 Free Base | Enasidenib ...)
Affinity DataIC50: 4.95E+3nMAssay Description:Inhibition of full length C-terminal His8 tagged IDH1 R132H mutant (1 to 414 residues) (unknown origin) homodimer expressed in Escherichia coli BE3 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed