Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50011121
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545077(CHEMBL4642085)
Affinity DataIC50: 171nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 253nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545078(CHEMBL4645055)
Affinity DataIC50: 530nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 540nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545079(CHEMBL4635807)
Affinity DataIC50: 550nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545078(CHEMBL4645055)
Affinity DataIC50: 646nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545079(CHEMBL4635807)
Affinity DataIC50: 673nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545077(CHEMBL4642085)
Affinity DataIC50: 680nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 720nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545077(CHEMBL4642085)
Affinity DataIC50: 750nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545078(CHEMBL4645055)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545080(CHEMBL4642867)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545080(CHEMBL4642867)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545079(CHEMBL4635807)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545080(CHEMBL4642867)
Affinity DataIC50: 4.31E+3nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545084(CHEMBL4649073)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545082(CHEMBL4639515)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545084(CHEMBL4649073)
Affinity DataIC50: 1.79E+4nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545083(CHEMBL4645240)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545083(CHEMBL4645240)
Affinity DataIC50: 2.55E+4nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545081(CHEMBL4635773)
Affinity DataIC50: 3.43E+4nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545084(CHEMBL4649073)
Affinity DataIC50: 5.67E+4nMAssay Description:Inhibition of His6/GST-tagged human SIRT1 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 10 mins by rev...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545081(CHEMBL4635773)
Affinity DataIC50: 6.08E+4nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 7.89E+4nMAssay Description:Inhibition of tRNA-activated His6-tagged human SIRT7 deacetylation activity using acetyl-lysine as substrate in presence of beta-NAD+ after 30 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545081(CHEMBL4635773)
Affinity DataIC50: 9.09E+4nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545082(CHEMBL4639515)
Affinity DataIC50: 1.15E+5nMAssay Description:Inhibition of His6-tagged human SIRT2 deacetylation activity using SIRT1 acetyl-lysine as substrate in presence of beta-NAD+ after 12 mins by reverse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545082(CHEMBL4639515)
Affinity DataIC50: 1.77E+5nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545083(CHEMBL4645240)
Affinity DataIC50: 2.17E+5nMAssay Description:Inhibition of His6-tagged human SIRT3 deacetylation activity using SIRT3 acetyl-lysine as substrate substrate in presence of beta-NAD+ after 10 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 3.90E+5nMAssay Description:Inhibition of His6-tagged human SIRT6 demyristoylation activity using myristoyl-lysine substrate in presence of beta-NAD+ after 12 mins by reversed-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50545085(CHEMBL4643590)
Affinity DataIC50: 4.43E+5nMAssay Description:Inhibition of His6-tagged human SIRT5 desuccinylation activity using succinyl-lysine as substrate in presence of beta-NAD+ after 5 mins by reversed-p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed