Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50007975
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataKd:  7.60nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataKd:  3.20nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataEC50:  52nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataEC50:  12nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  133nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataKd:  8.70nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataEC50:  27nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataKd:  1.40nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  155nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataEC50:  89nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataEC50:  88nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  209nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataKd:  3.20nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataKd:  1.40nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataKd:  8.70nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataEC50:  155nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataEC50:  27nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  209nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514587(CHEMBL4483666)
Affinity DataEC50:  52nMAssay Description:Agonist activity at rat IP3R1 expressed in human HEK cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50514586(CHEMBL4578747)
Affinity DataEC50:  12nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50075183(1D-myo-inositol 1,4,5-tris(dihydrogen phosphate) |...)
Affinity DataEC50:  132nMAssay Description:Agonist activity at rat IP3R1 expressed in DT40 cells assessed as increase in calcium release by Mag-fluo4 dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetInositol 1,4,5-trisphosphate receptor type 1(Rat)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50184325(2-[5-(6-amino-9H-9-purinyl)-2-hydroxymethyl-4-oxyp...)
Affinity DataKd:  7.60nMAssay Description:Displacement of [3H]IP3 from rat IP3R1 expressed in human HEK cells assessed as dissociation constant by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed