Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50007080
TargetC-X-C chemokine receptor type 2(Mouse)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506088(CHEMBL4462143)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of CXCR2-mediated chemotaxis in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50302098(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Affinity DataIC50: 0.120nMAssay Description:Antagonist activity at CXCR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506082(CHEMBL4574181)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]IL-8 from human CXCR2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506084(CHEMBL4465379)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at CXCR2 (unknown origin) by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50140791(1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...)
Affinity DataIC50: 6nMAssay Description:Displacement of [125I]IL-8 from CXCR2 (unknown origin) stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506090(CHEMBL4472754)
Affinity DataIC50: 17nMAssay Description:Antagonist activity at CXCR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506085(CHEMBL4473520)
Affinity DataIC50: 30nMAssay Description:Displacement of [125I]IL-8 from CXCR2 in human neutrophils incubated for 3 hrs by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50113628([5-(4-Fluoro-phenylcarbamoyl)-pyridin-2-ylsulfanyl...)
Affinity DataIC50: 42nMAssay Description:Antagonist activity at CXCR2 in human neutrophils assessed as reduction in GRO-alpha mediated chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50221044(CHEMBL309253)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at CXCR2 in human neutrophils assessed as reduction in GROalpha stimulated intracellular calcium mobilisation by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506083(CHEMBL4466314)
Affinity DataIC50: 48nMAssay Description:Antagonist activity at CXCR2 (unknown origin) stably expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in IL-8-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506085(CHEMBL4473520)
Affinity DataIC50: 230nMAssay Description:Displacement of [125I]IL-8 from CXCR1 in human neutrophils incubated for 3 hrs by gamma counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50140794(1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea | 1-(2-...)
Affinity DataIC50: 320nMAssay Description:Displacement of [125I]IL-8 from CXCR2 (unknown origin) stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506081(CHEMBL4527955)
Affinity DataIC50: 2.50E+3nMAssay Description:Antagonist activity at CXCR2 (unknown origin) expressed in human U2OS cells cp-expressing betaarrestin-2/TEV protease and beta lactamase assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50140791(1-(3-Bromo-4-cyano-2-hydroxy-phenyl)-3-(2-bromo-ph...)
Affinity DataIC50: 2.60E+3nMAssay Description:Displacement of [125I]IL-8 from CXCR1 (unknown origin) stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506083(CHEMBL4466314)
Affinity DataIC50: 2.90E+3nMAssay Description:Antagonist activity at CXCR1 (unknown origin) stably expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in IL-8-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506091(CHEMBL4562144)
Affinity DataIC50: 6.30E+3nMAssay Description:Antagonist activity at CXCR2 in human U2OS cells assessed as effect on beta-arrestin2 recruitment by CCF4-AM staining based Tango assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506087(CHEMBL1417864)
Affinity DataIC50: 7.60E+3nMAssay Description:Antagonist activity at CXCR2 (unknown origin) expressed in human U2OS cells cp-expressing betaarrestin-2/TEV protease and beta lactamase assessed as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506086(CHEMBL4482876)
Affinity DataIC50: 7.80E+3nMAssay Description:Antagonist activity at GFP-tagged CXCR2 (unknown origin) expressed in 293T cells assessed as suppression of IL-8-induced inhibition of forskolin-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50506089(CHEMBL4536494)
Affinity DataIC50: 1.48E+4nMAssay Description:Antagonist activity at CXCR2 (unknown origin) stably expressed in HEK293 cells co-expressing Galpha16 assessed as reduction in IL-8-induced intracell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 1(Human)
Hangzhou Institute of Innovative Medicine

Curated by ChEMBL
LigandPNGBDBM50140794(1-(2-Hydroxy-4-nitro-phenyl)-3-phenyl-urea | 1-(2-...)
Affinity DataIC50: 1.82E+4nMAssay Description:Displacement of [125I]IL-8 from CXCR1 (unknown origin) stably expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed