Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50008486
TargetHistamine H4 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human H4 receptor expressed in CHO-K1 cells co-expressing G protein alpha16 assessed as inhibition of histamine-induced calciu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519737(CHEMBL4535978)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519736(CHEMBL4457747)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519743(CHEMBL4541016)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519741(CHEMBL4437775)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519740(CHEMBL4528980)
Affinity DataIC50: 6.07E+3nMAssay Description:Inhibition of BuChE in human plasma using butyrylthiocholine iodide substrate by Ellman's protocol based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519739(CHEMBL4443523)
Affinity DataIC50: 7.22E+3nMAssay Description:Inhibition of BuChE in human plasma using butyrylthiocholine iodide substrate by Ellman's protocol based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 7.83E+3nMAssay Description:Inhibition of BuChE in human plasma using butyrylthiocholine iodide substrate by Ellman's protocol based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519740(CHEMBL4528980)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519738(CHEMBL4473509)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50101817(CHEBI:7565 | Adalat | Adalat Cc | Afeditab Cr | BA...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50519745(CHEMBL4518949)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519739(CHEMBL4443523)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
LigandPNGBDBM50519744(CHEMBL4459907)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of voltage-dependent L-type calcium channel in 70 mM K+-induced human SH-SY5Y cells assessed as blocking of depolarization-induced Ca2+ up...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM9019(CHEMBL45 | N-[2-(5-methoxy-1H-indol-3-yl)ethyl]ace...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519742(CHEMBL4469017)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519739(CHEMBL4443523)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519746(CHEMBL4455698)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519740(CHEMBL4528980)
Affinity DataKi:  425nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519735(CHEMBL4573309)
Affinity DataKi:  565nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
UBFC

Curated by ChEMBL
LigandPNGBDBM50519745(CHEMBL4518949)
Affinity DataKi:  1.62E+3nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from human H3 receptor expressed in HEK293 cell membranes incubated for 60 mins by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed