Compile Data Set for Download or QSAR
Report error Found 90 Enz. Inhib. hit(s) with all data for entry = 50009652
TargetThiopurine S-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TPMT expressed in Escherichia coli assessed as reduction in SAH level using 6-mercaptopurine as substrate in presence of SAM incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetThiopurine S-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TPMT expressed in Escherichia coli assessed as reduction in SAH level using 6-mercaptopurine as substrate in presence of SAM incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndolethylamine N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of wild type human INMT expressed in Escherichia coli using tryptamine as substrate in presence of SAM incubated for 30 mins by MTase-Glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetIndolethylamine N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of wild type human INMT expressed in Escherichia coli using tryptamine as substrate in presence of SAM incubated for 30 mins by MTase-Glo ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human DNMT3a expressed in insect sf9 cells assessed as reduction in methylated poly(dI-dC)-Poly(dI-dC) level using poly(dI-dC)-poly(dI-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 3A(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of human DNMT3a expressed in insect sf9 cells assessed as reduction in methylated poly(dI-dC)-Poly(dI-dC) level using poly(dI-dC)-poly(dI-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EHMT1 expressed in Escherichia coli assessed as reduction in methylated histone H3 full length using histone H3 full length as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EHMT1 expressed in Escherichia coli assessed as reduction in methylated histone H3 full length using histone H3 full length as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DOT1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT1 expressed in Escherichia coli assessed as reduction in methylated histone H4 full length level using histone H4 full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ASH1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human G9a expressed in Escherichia coli assessed as reduction in methylated histone H3 full length using histone H3 full length level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SETDB1 expressed in sf9 insect cells assessed as reduction in methylated histone H3 full length level using histone H3 full lengt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DOT1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human G9a expressed in Escherichia coli assessed as reduction in methylated histone H3 full length using histone H3 full length level a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PRMT1 expressed in Escherichia coli assessed as reduction in methylated histone H4 full length level using histone H4 full length...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ASH1L expressed in Escherichia coli assessed as reduction in methylated polynucleosome level using polynucleosome as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530711(CHEMBL4553052)
Affinity DataKi:  0.191nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530711(CHEMBL4553052)
Affinity DataKi:  0.191nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530731(CHEMBL4580446)
Affinity DataKi:  0.240nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530731(CHEMBL4580446)
Affinity DataKi:  0.240nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataKi:  0.501nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataKi:  0.501nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataKi:  0.501nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530712(CHEMBL4591248)
Affinity DataKi:  0.501nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530723(CHEMBL4455627)
Affinity DataKi:  1.90nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530723(CHEMBL4455627)
Affinity DataKi:  1.90nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530737(CHEMBL4449355)
Affinity DataKi:  2.60nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530737(CHEMBL4449355)
Affinity DataKi:  2.60nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530724(CHEMBL4519184)
Affinity DataKi:  3.40nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530724(CHEMBL4519184)
Affinity DataKi:  3.40nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530735(CHEMBL4435488)
Affinity DataKi:  4.70nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530735(CHEMBL4435488)
Affinity DataKi:  4.70nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530727(CHEMBL4457046)
Affinity DataKi:  5nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530727(CHEMBL4457046)
Affinity DataKi:  5nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530738(CHEMBL4473236)
Affinity DataKi:  6.80nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530738(CHEMBL4473236)
Affinity DataKi:  6.80nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530726(CHEMBL4587553)
Affinity DataKi:  8.90nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530726(CHEMBL4587553)
Affinity DataKi:  8.90nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530720(CHEMBL4565052)
Affinity DataKi:  17nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530720(CHEMBL4565052)
Affinity DataKi:  17nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530725(CHEMBL4435314)
Affinity DataKi:  32nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530725(CHEMBL4435314)
Affinity DataKi:  32nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530728(CHEMBL4584198)
Affinity DataKi:  35nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530728(CHEMBL4584198)
Affinity DataKi:  35nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530715(CHEMBL4466178)
Affinity DataKi:  55nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530715(CHEMBL4466178)
Affinity DataKi:  55nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530719(CHEMBL4554139)
Affinity DataKi:  58nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNicotinamide N-methyltransferase(Human)
Biokin

Curated by ChEMBL
LigandPNGBDBM50530719(CHEMBL4554139)
Affinity DataKi:  58nMAssay Description:Inhibition of N-terminal His6-tagged wild type human NNMT expressed in Escherichia coli NiCo21(DE3) assessed as reduction in 1-methylquinolinium leve...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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