Compile Data Set for Download or QSAR
Report error Found 80 Enz. Inhib. hit(s) with all data for entry = 50009433
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataEC50:  10nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to ULK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  4.20nMAssay Description:Binding affinity to TTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek10(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.200nMAssay Description:Binding affinity to NEK10 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253928(US9464092, T | US9527857, T | US10189849, Compound...)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK4/cyclinD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528812(CHEMBL4582951)
Affinity DataEC50:  13nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528814(CHEMBL4436535)
Affinity DataEC50:  4nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528811(CHEMBL4441405)
Affinity DataEC50:  48nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50511933(CHEMBL4518287)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity to CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  6.5nMAssay Description:Binding affinity to human FLT3 ITD mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK4/cyclinD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  22nMAssay Description:Binding affinity to human FLT3 D385V mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to SNARK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253928(US9464092, T | US9527857, T | US10189849, Compound...)
Affinity DataEC50: <100nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253928(US9464092, T | US9527857, T | US10189849, Compound...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human CDK4/cyclinD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528816(CHEMBL4457608 | US11370779, Compound 13)
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528809(CHEMBL4589249)
Affinity DataIC50: 3nMAssay Description:Competitive reversible inhibition of recombinant full-length His-tagged human CDK9/cyclin T expressed in baculovirus infected insect cells using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3nMAssay Description:Competitive reversible inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528809(CHEMBL4589249)
Affinity DataIC50: 4nMAssay Description:Competitive reversible inhibition of recombinant full-length His-tagged human CDK9/cyclin T expressed in baculovirus infected insect cells using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM253928(US9464092, T | US9527857, T | US10189849, Compound...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human CDK6/cyclin D3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM106950(US8592581, 1)
Affinity DataIC50: 5nMAssay Description:Competitive reversible inhibition of CDK2/cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-Y/Cyclin-dependent kinase 16(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528810(CHEMBL4580787 | US12187701, Compound FMF-04-159-2)
Affinity DataIC50: 10nMAssay Description:Competitive irreversible inhibition of CDK16/cyclin Y (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528818(CHEMBL4439321)
Affinity DataIC50: 19nMAssay Description:Competitive reversible inhibition of recombinant full-length His-tagged human CDK9/cyclin T expressed in baculovirus infected insect cells using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528815(CHEMBL4468670)
Affinity DataIC50: 20nMAssay Description:Competitive irreversible inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528812(CHEMBL4582951)
Affinity DataIC50: 20nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347389(CHEMBL1801932)
Affinity DataIC50: 21nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM106950(US8592581, 1)
Affinity DataIC50: 23nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528814(CHEMBL4436535)
Affinity DataIC50: 23nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) using 5-FAM YSPTSPSYSPTSPSYSPTSPSKKKK as substrate in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM106950(US8592581, 1)
Affinity DataIC50: 26nMAssay Description:Competitive reversible inhibition of CDK9/CyclinT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 30nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50526797(Ct-7001 | Ct7001 | ICEC-0942 | ICEC0942 | Samuraci...)
Affinity DataIC50: 40nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50526795(CHEMBL4450322)
Affinity DataIC50: 53nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 13/Cyclin-K(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528813(CHEMBL4163879)
Affinity DataIC50: 69nMAssay Description:Competitive irreversible inhibition of CDK13/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528812(CHEMBL4582951)
Affinity DataIC50: 84nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) using 5-FAM YSPTSPSYSPTSPSYSPTSPSKKKK as substrate in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-Y(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528810(CHEMBL4580787 | US12187701, Compound FMF-04-159-2)
Affinity DataIC50: 88nMAssay Description:Competitive irreversible inhibition of CDK14/cyclin Y (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 90nMAssay Description:Competitive reversible inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528811(CHEMBL4441405)
Affinity DataIC50: 112nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) using 5-FAM YSPTSPSYSPTSPSYSPTSPSKKKK as substrate in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528813(CHEMBL4163879)
Affinity DataIC50: 158nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528814(CHEMBL4436535)
Affinity DataIC50: 205nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) using 5-FAM YSPTSPSYSPTSPSYSPTSPSKKKK as substrate in presence of 2 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM7533(2,6,9-Trisubstituted purine deriv. 28 | (2R)-2-[[6...)
Affinity DataIC50: 220nMAssay Description:Competitive reversible inhibition of CDK2/cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528814(CHEMBL4436535)
Affinity DataIC50: 226nMAssay Description:Competitive irreversible inhibition of CDK9/cyclin T (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 238nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) in presence of 1 mM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 250nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM253941(US9464092, GG | US9527857, GG)
Affinity DataIC50: 280nMAssay Description:Inhibition of CDK9/cyclin H (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528811(CHEMBL4441405)
Affinity DataIC50: 312nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528814(CHEMBL4436535)
Affinity DataIC50: 367nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 12(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50110178(CHEMBL3603847 | US10787436, Compound I-23)
Affinity DataIC50: 371nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50528818(CHEMBL4439321)
Affinity DataIC50: 380nMAssay Description:Competitive reversible inhibition of recombinant full-length His-tagged human CDK9/cyclin T expressed in baculovirus infected insect cells using biot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
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