Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50006867
TargetDNA excision repair protein ERCC-1/repair endonuclease XPF(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataKd:  100nMAssay Description:Binding affinity to human His6-tagged ERCC1-XPF expressed in Escherichia coli BL21 (DE3) by spectrofluorimetric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA repair endonuclease XPF(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 330nMAssay Description:Inhibition of human His6-tagged ERCC1-XPF endonuclease activity expressed in Escherichia coli BL21 (DE3) using [6-FAM-5'-CAGCGCTCGG(20T)CCGAGCGCTG-3'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDNA repair endonuclease XPF(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of human His6-tagged ERCC1-XPF endonuclease activity expressed in Escherichia coli BL21 (DE3) using [6-FAM-5'-CAGCGCTCGG(20T)CCGAGCGCTG-3'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM50504115(CHEMBL4470176)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Alberta

Curated by ChEMBL
LigandPNGBDBM81244(cid_421105 | 4-[(6-chloro-2-methoxy-9-acridinyl)am...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed