Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50009109
TargetAngiopoietin-1 receptor(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GST-tagged TIE2 (unknown origin) using biotin-Ahx-EPKDDAYPLYSDFG peptide as substrate by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Mouse)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse VEGFR-2 (785 to 1376 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PDGFR beta (561 to 1106 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Mouse)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of mouse VEGFR-3 (818 to 1363 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of BRAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 7nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 30nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50363397(CHEMBL1946170 | REGORAFENIB | US10183928, Regorafe...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 60nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 80nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 110nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525513(CHEMBL4558790)
Affinity DataIC50: 120nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 130nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 130nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 150nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 150nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525510(CHEMBL4574832)
Affinity DataIC50: 170nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 170nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525507(CHEMBL4566054)
Affinity DataIC50: 190nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525506(CHEMBL4448435)
Affinity DataIC50: 220nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525512(CHEMBL4465126)
Affinity DataIC50: 220nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 250nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 260nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 280nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525509(CHEMBL4590013)
Affinity DataIC50: 280nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525508(CHEMBL4549103)
Affinity DataIC50: 290nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525514(CHEMBL4469216)
Affinity DataIC50: 340nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525510(CHEMBL4574832)
Affinity DataIC50: 370nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 390nMAssay Description:Inhibition of PDGFR beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525507(CHEMBL4566054)
Affinity DataIC50: 410nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 410nMAssay Description:Inhibition of RAF1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525506(CHEMBL4448435)
Affinity DataIC50: 410nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525498(CHEMBL4474945)
Affinity DataIC50: 420nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525508(CHEMBL4549103)
Affinity DataIC50: 440nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525500(CHEMBL4539297)
Affinity DataIC50: 480nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525496(CHEMBL4449189)
Affinity DataIC50: 480nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525517(CHEMBL4467107)
Affinity DataIC50: 490nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525503(CHEMBL4438418)
Affinity DataIC50: 570nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525512(CHEMBL4465126)
Affinity DataIC50: 640nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM16673(Xarelto | BAY439006 | CHEMBL1336 | BAY 43-9006 | 4...)
Affinity DataIC50: 670nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525493(CHEMBL4474922)
Affinity DataIC50: 740nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525497(CHEMBL4561629)
Affinity DataIC50: 950nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525509(CHEMBL4590013)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human wild type BRAF by Kinase-Glo luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525516(CHEMBL4470636)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human N-terminal GST tagged VEGFR-2 expressed in baculovirus infected Sf9 cells using poly (Glu,Tyr) 4:1 as substrate in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
National Research Centre

Curated by ChEMBL
LigandPNGBDBM50525511(CHEMBL4573547)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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