Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50007774
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50512479(CHEMBL4456440)
Affinity DataIC50: 0.0610nMAssay Description:Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 0.0620nMAssay Description:Inhibition of human N-terminal FLAG-tagged PDE10A (1 to 90 residues) expressed in using African green monkey COS7 cells using [3H]cAMP or [3H]cGMP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 289nMAssay Description:Inhibition of PDE4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 437nMAssay Description:Inhibition of PDE5A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 561nMAssay Description:Inhibition of PDE6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM14754(CHEMBL19224 | 1-[(3,4-dimethoxyphenyl)methyl]-6,7-...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 7B(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE8A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE9A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM144390(US8969376, 1.006)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE11A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed