Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50007844
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50513256(CHEMBL4442995)
Affinity DataIC50: 620nMAssay Description:Inhibition of P-gp in HEK293/ABCB1 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 1 uM incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50513257(CHEMBL4215931)
Affinity DataIC50: 700nMAssay Description:Inhibition of P-gp in human NCI-H460/R cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in doxorubicin IC50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50513256(CHEMBL4442995)
Affinity DataIC50: 920nMAssay Description:Inhibition of P-gp in HEK293/ABCB1 cells assessed as potentiation of cisplatin-induced cytotoxicity by measuring cisplatin IC50 at 2 uM incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50367247(Quinamm | Quinsan | QUININE | cid_3034034)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of P-gp-mediated Rhodamine-123 efflux in human MCF-7/DOX cells assessed as Rhodamine-123 accumulation preincubated for 15 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50418089(Limonin)
Affinity DataIC50: 1.91E+4nMAssay Description:Inhibition of P-gp in human Caco2 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring reduction in doxorubicin IC50 at 2....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM50042987(1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one (4...)
Affinity DataIC50: 2.49E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Central University of Punjab

Curated by ChEMBL
LigandPNGBDBM26660(3,7-dihydroxy-2-phenyl-4H-chromen-4-one | CHEMBL21...)
Affinity DataIC50: 1.25E+7nMAssay Description:Inhibition of P-gp in human HK2 cells assessed as Rhodamine-123 accumulation by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed