Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50007571
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataKd:  27nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataIC50: 132nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510627(CHEMBL4587609)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataIC50: 2.29E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50013224(CHEMBL351355 | Pyrrolidin-3-yl-acetic acid | Pyrro...)
Affinity DataIC50: 4.07E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510629(CHEMBL4539697)
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | cid_119 | Gamma-A...)
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium- and chloride-dependent GABA transporter 2(Mouse)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataIC50: 5.37E+4nMAssay Description:Inhibition of mouse GAT2 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510630(CHEMBL4586784)
Affinity DataIC50: 6.76E+4nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as reduction in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039251(CHEMBL1027 | Gabitril | 1-[4,4-Bis-(3-methyl-4,5-d...)
Affinity DataKi:  37nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510628(CHEMBL4464729)
Affinity DataKi:  389nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510627(CHEMBL4587609)
Affinity DataKi:  407nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Ludwig Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50510629(CHEMBL4539697)
Affinity DataKi:  692nMAssay Description:Inhibition of NO711 binding to mouse GAT1 expressed in HEK293 cell membranes assessed as reduction in NO711 binding at incubated for 4 hrs in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed