Compile Data Set for Download or QSAR
Report error Found 15 Enz. Inhib. hit(s) with all data for entry = 50012022
TargetNuclear receptor subfamily 1 group I member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataEC50: >2.70E+3nMAssay Description:Transactivation of PXR (unknown origin) assessed as CYP450 inductionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 66nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50553286(CHEMBL4794465)
Affinity DataIC50: 200nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 200nMAssay Description:Inhibition of CYP3A4 in human liver microsomes measured after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50553286(CHEMBL4794465)
Affinity DataIC50: 690nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human ERG by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50553286(CHEMBL4794465)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetUDP-glucuronosyltransferase 1A1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human UGT1A1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458163(CHEMBL4209316)
Affinity DataKi:  8.30E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed