Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50008309
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50127204(CHEMBL3628602)
Affinity DataIC50: 30nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 67nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 72nMAssay Description:Inhibition of human IDO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50321330(CHEMBL4166624)
Affinity DataEC50:  77nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 740nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataIC50: 900nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma-induced human HeLa cells assessed as reduction in L-kynurenine level after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 2.94E+3nMAssay Description:Inhibition of human TDO expressed in Escherichia coli at using L-tryptophan as substrate after 1 hr by UV absorption analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50517807(CHEMBL4570374)
Affinity DataIC50: 7.54E+3nMAssay Description:Inhibition of human TDO expressed in human A172 assessed as reduction in kynurenine formation using L-tryptophan as substrate after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed