Compile Data Set for Download or QSAR
Report error Found 170 Enz. Inhib. hit(s) with all data for entry = 50007595
Target5-hydroxytryptamine receptor 1A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510842(CHEMBL4533184)
Affinity DataEC50:  107nMAssay Description:Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataEC50:  0.120nMAssay Description:Agonist activity at human 5H1A receptor expressed in HEK293 cells incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510837(CHEMBL4467284)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9012(7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)am...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9007(7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptanoic...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510845(CHEMBL4556734)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9008(6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510846(CHEMBL4590945)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510847(CHEMBL4455677)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9013(6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic ...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9014(N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-7-(1,2,3,4-te...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9015(6-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510848(CHEMBL4468781)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9017(7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)am...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510849(CHEMBL4579667)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9006(N-[2-(1H-indol-3-yl)ethyl]-6-(1,2,3,4-tetrahydroac...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9011(6-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)am...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510865(CHEMBL4532770)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9018(N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-6-(1,2,3,4-te...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510867(CHEMBL4469239)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510868(CHEMBL4448350)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510869(CHEMBL4443426)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9009(7-(6-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510870(CHEMBL4543251)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM9016(6-(8-Chloro-1,2,3,4-tetrahydro-acridin-9-ylamino)-...)
Affinity DataIC50: 0nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50359391(CHEMBL1929421)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using p-tyramine as substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8963(N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8964(CHEMBL75274 | N-[8-(1,2,3,4-tetrahydroacridin-9-yl...)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10469(CHEMBL424707 | Bis-THA inhibitor 8 | N-[9-(1,2,3,4...)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510840(CHEMBL4456928)
Affinity DataIC50: 0.860nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510844(CHEMBL4451532)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510843(CHEMBL4466652)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510840(CHEMBL4456928)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human Acetylcholinesterase using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellman's met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50433323(CHEMBL2376472)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated 5 mins followed by substrate addition and measured after 2 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50: 4.23nMAssay Description:Inhibition of bovine erythrocyte acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM132072(US8841453, 2)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human plasma butyrylcholinesterase using butyrylthiocholine as substrate preincubated for 30 mins followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50006627(CHEMBL3235503)
Affinity DataIC50: 5nMAssay Description:Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510834(CHEMBL4569511)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition by E...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50006627(CHEMBL3235503)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8979(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510853(CHEMBL4563881)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50175503(Dimethyl-carbamic acid (R)-2-methyl-1-[2-(4-nitro-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat synaptosome SERT assessed as reduction in [3H]5-HT uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50080157((RS)-tacrine(10)-hupyridone | 5-[10-(1,2,3,4-Tetra...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of rat cortex homogenate acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by Ellman's...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 11nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholinesterase(Human)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM8960(2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
Csir-Central Drug Research Institute

Curated by ChEMBL
LigandPNGBDBM50510853(CHEMBL4563881)
Affinity DataIC50: 14nMAssay Description:Inhibition of mouse brain acetylcholinesterase by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
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