Compile Data Set for Download or QSAR
Report error Found 122 Enz. Inhib. hit(s) with all data for entry = 50009592
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530316(CHEMBL4455046)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530318(CHEMBL4526405)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530318(CHEMBL4526405)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530316(CHEMBL4455046)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530319(CHEMBL4556528)
Affinity DataKd:  600nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530324(CHEMBL1617004)
Affinity DataKd:  1.44E+4nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKd:  110nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataEC50:  100nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  4.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  4.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 assuming basal level of non-responsive P-alpha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530327(CHEMBL4449524)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530319(CHEMBL4556528)
Affinity DataKd:  600nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKd:  300nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKd:  110nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataEC50:  100nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530334(CHEMBL4476631)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530327(CHEMBL4449524)
Affinity DataKd:  7.00E+3nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataKd:  300nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataEC50:  5.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530334(CHEMBL4476631)
Affinity DataKd:  6.00E+3nMAssay Description:Binding affinity to recombinant human GST-tagged CK2alpha after 120 secs by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530324(CHEMBL1617004)
Affinity DataKd:  1.44E+4nMAssay Description:Allosteric binding affinity to human CK2alpha (1 to 335 residues) at 300 uM secs by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in p21 phosphorylation at Thr145 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataEC50:  5.30E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as reduction in STAT3 phosphorylation at Y705 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDual specificity protein kinase CLK2(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant DyrK1b by fluorescence-based immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant DyrK1b by fluorescence-based immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human recombinant DyrK1a by fluorescence-based immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human recombinant DyrK1a by fluorescence-based immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50132260(CHEMBL105442 | US8575391, 341 | CI-1040 | 2-(2-chl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530315(CHEMBL4520531)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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