Compile Data Set for Download or QSAR
Report error Found 13 Enz. Inhib. hit(s) with all data for entry = 50007162
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506874(CHEMBL4161103)
Affinity DataIC50: 2.40nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 4.90nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.59E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50: 3.49E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 4.46E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50075373(CHEMBL348475 | 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tet...)
Affinity DataIC50: 5.24E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM81939(NSC_62969 | VERAPAMIL | CAS_52-53-9)
Affinity DataIC50: 6.15E+3nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50420186(ZOSUQUIDAR | ZOSUQUIDAR TRIHYDROCHLORIDE)
Affinity DataIC50: 1.23E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.27E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 1.72E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 2.12E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 3.50E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University)

Curated by ChEMBL
LigandPNGBDBM50506873(CHEMBL4435412)
Affinity DataIC50: 4.98E+4nMAssay Description:Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed