Compile Data Set for Download or QSAR
Report error Found 48 Enz. Inhib. hit(s) with all data for entry = 50008600
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataIC50: 40nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442987(8-Bromotryptanthrin | CHEMBL72165)
Affinity DataIC50: 53nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442987(8-Bromotryptanthrin | CHEMBL72165)
Affinity DataIC50: 54nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442988(CHEMBL3087009)
Affinity DataIC50: 59nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(SMR000544298 | 8-fluoranylindolo[2,1-b]quinazoline...)
Affinity DataIC50: 60nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataIC50: 61nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442988(CHEMBL3087009)
Affinity DataIC50: 62nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(SMR000544298 | 8-fluoranylindolo[2,1-b]quinazoline...)
Affinity DataIC50: 68nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataIC50: 101nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataIC50: 140nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442994(CHEMBL312537 | US10669273, Compound 5b)
Affinity DataIC50: 184nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataIC50: 194nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442994(CHEMBL312537 | US10669273, Compound 5b)
Affinity DataIC50: 215nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442989(CHEMBL3087010)
Affinity DataIC50: 227nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442989(CHEMBL3087010)
Affinity DataIC50: 229nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50: 241nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 242nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 260nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 398nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50: 503nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 671nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442990(CHEMBL1276265)
Affinity DataIC50: 733nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(SMR000544298 | 8-fluoranylindolo[2,1-b]quinazoline...)
Affinity DataIC50: 937nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442987(8-Bromotryptanthrin | CHEMBL72165)
Affinity DataIC50: 937nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442990(CHEMBL1276265)
Affinity DataIC50: 957nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442988(CHEMBL3087009)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442994(CHEMBL312537 | US10669273, Compound 5b)
Affinity DataIC50: 3.23E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataIC50: 3.94E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataIC50: 9.81E+3nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442989(CHEMBL3087010)
Affinity DataIC50: 4.48E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50: 6.45E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442990(CHEMBL1276265)
Affinity DataIC50: 2.24E+5nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50241727(L-1-methyl-tryptophan | (S)-2-amino-3-(1-methyl-1H...)
Affinity DataIC50: 3.80E+5nMAssay Description:Inhibition of IDO1 (unknown origin) using L-Trp as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442991(GNF-Pf-3777 | CHEMBL432537 | US10669273, Compound ...)
Affinity DataKi:  215nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM48009(SMR000544298 | 8-fluoranylindolo[2,1-b]quinazoline...)
Affinity DataKi:  336nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442987(8-Bromotryptanthrin | CHEMBL72165)
Affinity DataKi:  356nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50240612(CHEMBL306946 | Indolo[2,1-b]quinazoline-6,12-dione...)
Affinity DataKi:  581nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442994(CHEMBL312537 | US10669273, Compound 5b)
Affinity DataKi:  834nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442995(CHEMBL3086870)
Affinity DataKi:  876nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442988(CHEMBL3087009)
Affinity DataKi:  1.00E+3nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli using L-Trp as substrate after 10 to 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  7.47E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442989(CHEMBL3087010)
Affinity DataKi:  8.41E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520736(NSC-36398 | CHEMBL483206)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataKi:  2.17E+4nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50442990(CHEMBL1276265)
Affinity DataKi:  4.27E+4nMAssay Description:Mixed type uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50520736(NSC-36398 | CHEMBL483206)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed