Compile Data Set for Download or QSAR
Report error Found 23 Enz. Inhib. hit(s) with all data for entry = 50008595
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of STAT5 phosphorylation after 1 hr by immun...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of CrkL phosphorylation after 1 hr by immuno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL in human MEG01 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of ErK phosphorylation after 1 hr by immunob...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL T315I mutant (unknown origin) expressed in mouse BAF3 cells assessed as inhibition of BCR/ABL T315I mutant autophosphorylation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <30nMAssay Description:Inhibition of BCR/ABL in human KU812 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataEC50: <10nMAssay Description:Inhibition of BCR/ABL in human K562 cells assessed as inhibition of BCR/ABL autophosphorylation at Y245 site after 1 hr by immunoblotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520735(CHEMBL4519289)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of active wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of inactive wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of active wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520735(CHEMBL4519289)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of inactive wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of active wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 1nMAssay Description:Inhibition of inactive wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataIC50: 2nMAssay Description:Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520735(CHEMBL4519289)
Affinity DataIC50: 4nMAssay Description:Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520735(CHEMBL4519289)
Affinity DataIC50: 15nMAssay Description:Inhibition of active wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using ABLtide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50520734(CHEMBL4439424)
Affinity DataIC50: 17nMAssay Description:Inhibition of active wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using ABLtide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 43nMAssay Description:Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 92nMAssay Description:Inhibition of inactive wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells assessed as reduct...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | N-methyl-2-({3-[(E)-2-(pyridin-2-yl)et...)
Affinity DataIC50: 170nMAssay Description:Inhibition of active wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using ABLtide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of active wild type His-tagged ABL (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using ABLtide as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of active wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells using A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM13530(cid_5291 | STI571 | N-(4-methyl-3-{[4-(pyridin-3-y...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of inactive wild type His-tagged ABL T315I mutant (229 to 500 residues) (unknown origin) expressed in baculovirus infected sf9 cells asses...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed