Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50003331
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470500(CHEMBL4291334)
Affinity DataKd:  1.90E+4nMAssay Description:Binding affinity to human His-tagged MOF by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase(Tetrahymena thermophila (strain SB210))
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470511(CHEMBL4279596)
Affinity DataIC50: 300nMAssay Description:Inhibition of Tetrahymena Gcn5 (48 to 210 residues) using histone (3 to 20 residues) peptide substrate in presence of [14C]acetyl CoA by phosphor ima...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470498(CHEMBL4282866)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470503(CHEMBL4288384)
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470501(CHEMBL4290743)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470507(CHEMBL4291382)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470506(CHEMBL4280076)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470504(CHEMBL4286898)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470505(CHEMBL4279641)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetCREB-binding protein/Histone acetyltransferase p300(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of p300/CBP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470510(CHEMBL4290304)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50360449(CHEMBL1215739 | MG-149)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470509(CHEMBL4294792)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470502(CHEMBL4280681)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470499(CHEMBL4294738)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470500(CHEMBL4291334)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human His-tagged MOF using histone H4 substrate by radioactive acetylation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470508(CHEMBL4287978)
Affinity DataIC50: 7.40E+4nMAssay Description:Inhibition of human His-tagged MOF preincubated for 10 mins followed by biotin-labeled H4K16 substrate addition measured after 30 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470498(CHEMBL4282866)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50467835(CHEMBL217676)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged Gcn5 using H3 as substrate in presence of [3H]-acetyl-CoA by phosphor image analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470498(CHEMBL4282866)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50470498(CHEMBL4282866)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PRMT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed