Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50003279
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 23nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 27nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human EGFR L858R mutant expressed in baculovirus infected insect cells preincubated for 5 mins followed by ATP addition and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468985(CHEMBL4281426)
Affinity DataIC50: 46nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 91nMAssay Description:Inhibition of recombinant human GST-tagged HER2 (676-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468981(CHEMBL4284841)
Affinity DataIC50: 108nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataIC50: 130nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human EGFR T790M mutant expressed in baculovirus infected Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 137nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human EGFR T790M mutant expressed in baculovirus infected Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468982(CHEMBL4289728)
Affinity DataIC50: 205nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5445(N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...)
Affinity DataIC50: 225nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human EGFR T790M mutant expressed in baculovirus infected Sf21 insect cells preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human GST-tagged HER2 (676-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 250nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR (789-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468983(CHEMBL4282506)
Affinity DataIC50: 276nMAssay Description:Inhibition of GST-tagged recombinant human VEGFR (789-end) expressed in baculovirus infected Sf9 insect cells preincubated for 5 mins followed by ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468984(CHEMBL4288648)
Affinity DataIC50: 751nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468979(CHEMBL4280749)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Al-Azhar University

Curated by ChEMBL
LigandPNGBDBM50468980(CHEMBL4289083)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of EGFR in human HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed