Compile Data Set for Download or QSAR
Report error Found 75 Enz. Inhib. hit(s) with all data for entry = 50006778
LigandPNGBDBM50503299(CHEMBL4538736)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503300(CHEMBL4547874)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503313(CHEMBL4454263)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503298(CHEMBL4462146)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of kidney-type glutaminase in human BT20 cells assessed as reduction in glutamate levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM109086(US8604016, 670 | US9938267, Cmpd ID 670 | US107935...)
Affinity DataIC50: 5nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM416667(US10323028, Example 11(b) | (2R)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM416666(US10323028, Example 11(a) | (2S)-2-Methoxy-2-[3-me...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108726(US8604016, 1038 | US9938267, Cmpd ID 1038)
Affinity DataIC50: 10nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM278400(US10040788, Example 2(a) | (2S)-2-Methoxy-2-phenyl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503321(CHEMBL4540444)
Affinity DataIC50: 25nMAssay Description:Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM332752(US10196382, Example 1 | (2S)-2-[3-(Difluoromethoxy...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM387008((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM387025((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50: 40nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503289(CHEMBL4462220)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503296(CHEMBL4452754)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503291(CHEMBL4562029)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse kidney glutaminase assessed as ammonia formation using glutamine as substrate by Nessler's reagent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503294(CHEMBL4577734)
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse kidney glutaminase assessed as ammonia formation at 0.1 uM using glutamine as substrate by Nessler's reagent based assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM278471((1S)-2-methyl-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolid...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50178230(CHEMBL3814265 | US11191732, Example 5)
Affinity DataIC50: 70nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108684(US8604016, 264)
Affinity DataIC50: 72nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108715(US8604016, 295 | US9938267, Cmpd ID 295 | US107935...)
Affinity DataIC50: 80nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50400050(CHEMBL2177757 | US8604016, 1 | US9938267, Cmpd ID ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503309(CHEMBL4476215)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503308(CHEMBL4528646)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM404693(N-(pyridin-2-ylmethyl)-5-[4-(6- {2-[3-(trifluorome...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) using 1 mM glutamine as substrate preincubated for 10 mins by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM405185(N-(pyridin-2-ylmethyl)-1-[4-(6-{2-[3- (trifluorome...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) using 1 mM glutamine as substrate preincubated for 10 mins by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503307(CHEMBL4466771)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503306(CHEMBL4591144)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503305(CHEMBL4533926)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503315(CHEMBL4583483)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503303(CHEMBL4556025)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503316(CHEMBL4473972)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503295(CHEMBL4455802)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) using 1 mM glutamine as substrate preincubated for 10 mins by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503322(CHEMBL4555100)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM404721(5-(4-{4-[(pyridin-2- ylmethyl)carbamoyl]-1H- 1,2,3...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) using 1 mM glutamine as substrate preincubated for 10 mins by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50400050(CHEMBL2177757 | US8604016, 1 | US9938267, Cmpd ID ...)
Affinity DataIC50: 100nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50503297(CHEMBL4563113)
Affinity DataIC50: 100nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503319(CHEMBL4560800)
Affinity DataIC50: 110nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108586(US8604016, 159 | US9938267, Cmpd ID 159)
Affinity DataIC50: 110nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50178226(CHEMBL3813967)
Affinity DataIC50: 120nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 1.8 to 13 mM glutamine as substrate preincubated for 60 mins by resorufin dye bas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108590(US8604016, 163 | US9938267, Cmpd ID 163)
Affinity DataIC50: 130nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM278401((2R)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)
Affinity DataIC50: 160nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM278463(US10040789, Example 18 | US10040789, Example 4(b) ...)
Affinity DataIC50: 180nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50400050(CHEMBL2177757 | US8604016, 1 | US9938267, Cmpd ID ...)
Affinity DataIC50: 190nMAssay Description:Inhibition of human KGA (1 to 669 residues) preincubated for 20 mins using 7 mM glutamine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM108621(US8604016, 196 | US9938267, Cmpd ID 196)
Affinity DataIC50: 190nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50400050(CHEMBL2177757 | US8604016, 1 | US9938267, Cmpd ID ...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human GAC assessed as NADH formation using 10 mM glutamine as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM278482((2S)-2-(dimethylamino)-2-(4-methoxyphenyl)-N- | US...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human KGA (63 to 669 residues) preincubated for 15 mins using 50 mM glutamine as substrate by resorufin dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50503293(CHEMBL4436330)
Affinity DataIC50: 240nMAssay Description:Inhibition of GAC (unknown origin) assessed as NADH formation using 10 mM glutamine as substrate preincubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
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