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Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50002770
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN HYDRATE | CANAGLIFLOZIN | US10752604...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50315426((1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM150162(US8980829, EMPAGLIFLOZIN | empagliflozin | BI-1077...)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50396779(TOFOGLIFLOZIN)
Affinity DataIC50: 4nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50381554(CHEMBL2018096)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of SGLT2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50: 126nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50: 184nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 2(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50: 246nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462729(CHEMBL4238635)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462730(CHEMBL4248660)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Guangdong Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50462731(CHEMBL4238200)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as decrease in [14C]-AMG uptake preincubated for 10 mins followed by [14C]-AMG addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed