Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 50001308
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 28nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276143(CHEMBL4128547)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276139(CHEMBL4128509)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276141(CHEMBL4128353)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276145(CHEMBL4128630)
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276139(CHEMBL4128509)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276139(CHEMBL4128509)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276139(CHEMBL4128509)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human SIRT5 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 9.80E+4nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276139(CHEMBL4128509)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276141(CHEMBL4128353)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT5 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276142(CHEMBL4129734)
Affinity DataIC50: 2.37E+5nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276141(CHEMBL4128353)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276142(CHEMBL4129734)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human SIRT1 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276141(CHEMBL4128353)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276142(CHEMBL4129734)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human SIRT5 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276141(CHEMBL4128353)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human SIRT5 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50276142(CHEMBL4129734)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human SIRT6 (1 to 294 residues) expressed in Escherichia coli Rosetta (DE3) using H3K9AcWW as substrate preincubated for 15 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed
LigandPNGBDBM50276142(CHEMBL4129734)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human SIRT3 expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubated for 15 mins followed by substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2020
Entry Details Article
PubMed