Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) with all data for entry = 50001266
TargetAmyloid-beta precursor protein(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50163745(4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)viny...)
Affinity DataIC50: 138nMAssay Description:Displacement of [125I]IMPY from fibrillar amyloid beta 42 (unknown origin) after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274115(CHEMBL4127372 | US10550089, Example 2 | US10995072...)
Affinity DataIC50: 4.20E+3nMAssay Description:Antagonist activity at PAR2 in human 1321N1 cells assessed as inhibition of trypsin-induced intracellular calcium flux pretreated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274113(CHEMBL4128225)
Affinity DataIC50: 6.00E+3nMAssay Description:Antagonist activity at PAR2 in human HEK293 cells assessed as inhibition of trypsin-induced intracellular calcium flux pretreated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274114(CHEMBL4128763)
Affinity DataIC50: 6.60E+3nMAssay Description:Antagonist activity at PAR2 in human 1321N1 cells assessed as inhibition of trypsin-induced intracellular calcium flux pretreated for 60 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed
TargetProteinase-activated receptor 2(Human)
Advinus Therapeutics

Curated by ChEMBL
LigandPNGBDBM50274116(CHEMBL4126288)
Affinity DataIC50: 6.78E+4nMAssay Description:Antagonist activity at PAR2 in human HEK293 cells assessed as inhibition of SLIGRL-induced intracellular calcium flux preincubated for 10 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details Article
PubMed