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Report error Found 41 Enz. Inhib. hit(s) with all data for entry = 50018710
TargetGlucose-dependent insulinotropic receptor(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611788(CHEMBL5275303)
Affinity DataEC50:  24nMAssay Description:Agonist activity at human GPR119 expressed in HEK293S cells assessed as increase in intracellular cAMP level incubated for 45 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50543530(CHEMBL4646784)
Affinity DataEC50:  6nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells incubated for 1 hrs by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611803(CHEMBL5271268)
Affinity DataEC50:  50nMAssay Description:Agonist activity at FFAR1 (unknown origin) incubated for 16 hrs by Promoter-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFree fatty acid receptor 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM382129(4-(4-((4'-cyclopropyl-3,4,5,6-tetrahydro-[1,1'-bip...)
Affinity DataEC50:  50nMAssay Description:Agonist activity at FFA4 (unknown origin) expressed in CHO-K1 cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611778(CHEMBL5280836)
Affinity DataEC50:  71nMAssay Description:Agonist activity at human GPR40 expressed in HEK293 cells incubated for 18 to 24 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611787(CHEMBL5266838)
Affinity DataEC50:  2.80nMAssay Description:Agonist activity at human GPR119 expressed in CHO-K1 cells assessed as increase in intracellular cAMP level incubated for 5 mins by fluorescence anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFree fatty acid receptor 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50543523(CHEMBL4642294)
Affinity DataEC50:  220nMAssay Description:Agonist activity at human GPR120 expressed in CHO cells assessed as intracellular phosphorylated ERK incubated for 16 to 18 hrs by AlphaScreen SureFi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611802(CHEMBL5269668)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-7-amido-4-methylcoumarin as substrate incubated for 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50539421(CHEMBL4634355)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611799(CHEMBL5278252)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611800(CHEMBL5278621)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611797(CHEMBL5270520)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human GST-tagged PTP1B expressed in Escherichia coli using pNPP as substrate by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611798(CHEMBL5270313)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611786(CHEMBL5275453)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate incubated for 20 mins by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611801(CHEMBL5289102)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of DPP4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611782(CHEMBL5279562)
Affinity DataIC50: 75nMAssay Description:Inhibition of TC-PTP (unknown origin) using pNPP as substrate incubated for 5 mins by absorbance based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlucagon receptor(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611795(CHEMBL5277926)
Affinity DataIC50: 110nMAssay Description:Displacement of [125I]-glucagon from GCGR in Sprague-Dawley rat liver assessed as decrease in glucagon-stimulated CAMP production incubated for 45 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611790(CHEMBL4435163)
Affinity DataIC50: 240nMAssay Description:Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenol-alpha-D-glucopyranoside as substrate incubated for 15 mins by spectropho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611780(CHEMBL5274674)
Affinity DataIC50: 240nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611783(CHEMBL5268335)
Affinity DataIC50: 420nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate for 2 mins by spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetMaltase-glucoamylase(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611789(CHEMBL480722 | 3'-geranylchalconaringenin)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl-alpha-D-glucopyranoside as substrate incubated for 30 mins by spectrophotometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611779(CHEMBL5269314)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611792(CHEMBL3287959)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of FBPase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232095(CHEMBL4081501)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611781(CHEMBL5266281)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611793(CHEMBL3287977)
Affinity DataIC50: 2.98E+3nMAssay Description:Inhibition of FBPase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611779(CHEMBL5269314)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of TC-PTP (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlucagon receptor(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50280717(N-[6,7-Dichloro-3-((E)-styryl)-quinoxalin-2-yl]-N,...)
Affinity DataIC50: 4.00E+3nMAssay Description:Displacement of [125I]-glucagon from GCGR in Sprague-Dawley rat liver assessed as decrease in glucagon-stimulated CAMP production incubated for 45 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611791(CHEMBL1521269)
Affinity DataIC50: 4.51E+3nMAssay Description:Inhibition of FBPase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611794(CHEMBL3287957)
Affinity DataIC50: 5.61E+3nMAssay Description:Inhibition of FBPase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611785(CHEMBL5291433)
Affinity DataIC50: 6.25E+3nMAssay Description:Inhibition of human recombinant DPP4 using H-Gly-Pro-AMC as substrate incubated for 10 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50155447(1,3,6,7-tetrahydroxyxantone | 1,3,6,7-Tetrahydroxy...)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50232093(CHEMBL4072175)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetFructose-1,6-bisphosphatase 1(Rat)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611793(CHEMBL3287977)
Affinity DataIC50: 1.67E+5nMAssay Description:Inhibition of FBPase in rat Primary hepatocyte assessed as reduction in glucose productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50103521(CHEBI:8228 | Actos | Duetact | Pioglitazone | US20...)
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611784(CHEMBL5276430)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human recombinant DPP4 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetGlucagon receptor(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611796(ADOMEGLIVANT | Adomeglivant | Adomeglivant, (-)- |...)
Affinity DataKi:  6.60nMAssay Description:Inhibition of human GCGR receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611783(CHEMBL5268335)
Affinity DataKi:  260nMAssay Description:Competitive inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrate by Michaelis-Menten based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 9(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611784(CHEMBL5276430)
Affinity DataKi:  1.95E+4nMAssay Description:Inhibition of human recombinant DPP9 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 8(Human)
University of Kwazulu-Natal

Curated by ChEMBL
LigandPNGBDBM50611784(CHEMBL5276430)
Affinity DataKi:  3.75E+4nMAssay Description:Inhibition of human recombinant DPP8 using Gly-Pro-7-amido-4-methylcoumarin hydrobromide as substrate incubated for 30 mins by fluorescence microplat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed