Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50001714
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataKd:  6.00E+3nMAssay Description:Inhibition of human Keap1 kelch domain binding to Nrf2-ETGE peptide by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM335554(US9737525, Compound MIND4-17)
Affinity DataKd:  1.65E+4nMAssay Description:Binding affinity to recombinant human Keap1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321027(CHEMBL4175603)
Affinity DataEC50:  79nMAssay Description:Inhibition of Keap1/NRF2 interaction in human BEAS-2B cells assessed as upregulation of NQ01 after 48 hrs by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataKd:  2.28E+4nMAssay Description:Binding affinity to recombinant human Keap1 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321027(CHEMBL4175603)
Affinity DataIC50: 10nMAssay Description:Inhibition of human Keap1 kelch domain (321 to 609 residues) binding to TAMRA-labeled Nrf2-ETGE peptide after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321036(CHEMBL4160447)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length Flag/His-tagged Keap1 kelch domain (unknown origin)/full length Avi-tagged Nrf2 (unknown origin) interaction after 2.25 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321027(CHEMBL4175603)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length Flag/His-tagged Keap1 kelch domain (unknown origin)/full length Avi-tagged Nrf2 (unknown origin) interaction after 2.25 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321036(CHEMBL4160447)
Affinity DataIC50: 10nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50200467(CHEMBL3899754)
Affinity DataIC50: 140nMAssay Description:Inhibition of human Keap1 kelch domain binding to Nrf2-ETGE peptide preincubated for 15 mins followed by peptide addition measured after 30 mins by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50200460(CHEMBL3890847)
Affinity DataIC50: 750nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321306(CHEMBL4167678)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50109398(CHEMBL2381968)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321307(CHEMBL4167472)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321304(CHEMBL4165400)
Affinity DataIC50: 6.97E+4nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321303(CHEMBL4176009)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed
TargetNuclear factor erythroid 2-related factor 2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50321305(CHEMBL3186228)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Keap1 kelch domain (unknow origin)/Nrf2-ETGE peptide (unknown origin) interaction by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMed