Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) with all data for entry = 50002616
TargetProprotein convertase subtilisin/kexin type 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM217366(TVFTSWEEYLDWV | Pep2-8)
Affinity DataKd:  700nMAssay Description:Binding affinity to recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by biolayer interferometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460548(CHEMBL4227596)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of PCSK9 binding to LDLR in human HuH7 cells after 5 hrs by On-cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460550(CHEMBL4227325)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of recombinant human C-terminal His8-tagged PCSK9 expressed in Chinese hamster ovary cells by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetProprotein convertase subtilisin/kexin type 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460549(CHEMBL4228379)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of binding of full-length recombinant human PCSK9 (M1 to Q692 residues) expressed in HEK293 cells to full-length LDLR (A1 to A699 residues...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed