Compile Data Set for Download or QSAR
Report error Found 54 Enz. Inhib. hit(s) with all data for entry = 50001575
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285733(CHEMBL4163148)
Affinity DataEC50:  280nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285718(CHEMBL4161259)
Affinity DataEC50:  80nMAssay Description:Agonist activity at FXR (unknown origin) measured after 16 hrs in presence of CCF4-AM dye by cell-based GeneBlazer FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285616(CHEMBL4160849)
Affinity DataEC50:  80nMAssay Description:Agonist activity at FXR (unknown origin) measured after 16 hrs in presence of CCF4-AM dye by cell-based GeneBlazer FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285725(CHEMBL4161602)
Affinity DataEC50:  110nMAssay Description:Agonist activity at FXR (unknown origin) measured after 16 hrs in presence of CCF4-AM dye by cell-based GeneBlazer FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285712(CHEMBL4172477)
Affinity DataEC50:  60nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285726(CHEMBL4165675)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285727(CHEMBL4176961)
Affinity DataEC50:  240nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50250871(CHEMBL4071018)
Affinity DataEC50:  230nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50250872(CHEMBL4072790)
Affinity DataEC50:  290nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285728(CHEMBL4162386)
Affinity DataEC50:  370nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285729(CHEMBL4174157)
Affinity DataEC50:  230nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285730(CHEMBL4163456)
Affinity DataEC50:  230nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285731(CHEMBL4159008)
Affinity DataEC50:  110nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285732(CHEMBL4171065)
Affinity DataEC50:  230nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM21674(Chenodeoxycholic Acid | CDCA | (4R)-4-[(1S,2S,5R,7...)
Affinity DataEC50:  8.66E+3nMAssay Description:Agonist activity at human FXR assessed as recruitment of SRC1 peptide by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285734(CHEMBL4169184)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285718(CHEMBL4161259)
Affinity DataEC50:  120nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285735(CHEMBL4171466)
Affinity DataEC50:  300nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285736(CHEMBL4168123)
Affinity DataEC50:  150nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285737(CHEMBL4166934)
Affinity DataEC50:  300nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285725(CHEMBL4161602)
Affinity DataEC50:  230nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285738(CHEMBL4175639)
Affinity DataEC50:  700nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285739(CHEMBL4168436)
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285740(CHEMBL4163928)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM21675(6alpha-Ethyl-Chenodeoxycholic Acid | (4R)-4-[(1S,2...)
Affinity DataEC50:  180nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285741(CHEMBL4159036)
Affinity DataEC50:  300nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285619(CHEMBL4165830)
Affinity DataEC50:  420nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285709(CHEMBL4175974)
Affinity DataEC50:  300nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285617(CHEMBL4172216)
Affinity DataEC50:  100nMAssay Description:Agonist activity at FXR (unknown origin) measured after 16 hrs in presence of CCF4-AM dye by cell-based GeneBlazer FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285617(CHEMBL4172216)
Affinity DataEC50:  280nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285618(CHEMBL4165268)
Affinity DataEC50:  2.70E+3nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285619(CHEMBL4165830)
Affinity DataEC50:  70nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285620(CHEMBL4164682)
Affinity DataEC50:  20nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285621(CHEMBL4170310)
Affinity DataEC50:  80nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285616(CHEMBL4160849)
Affinity DataEC50:  90nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285622(CHEMBL4171793)
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285704(CHEMBL4175888)
Affinity DataEC50:  30nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285705(CHEMBL4169097)
Affinity DataEC50:  600nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285706(CHEMBL4173761)
Affinity DataEC50:  130nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285707(CHEMBL4166913)
Affinity DataEC50:  470nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285708(CHEMBL4172570)
Affinity DataEC50:  150nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285616(CHEMBL4160849)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285710(CHEMBL4165022)
Affinity DataEC50:  300nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285711(CHEMBL4160539)
Affinity DataEC50:  400nMAssay Description:Agonist activity at recombinant human GST-tagged FXR LBD (193 to 472 residues) expressed in baculovirus-infected insect cells assessed as recruitment...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285712(CHEMBL4172477)
Affinity DataEC50:  1.77E+3nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285617(CHEMBL4172216)
Affinity DataEC50:  280nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285621(CHEMBL4170310)
Affinity DataEC50:  160nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285704(CHEMBL4175888)
Affinity DataEC50:  520nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285713(CHEMBL4173597)
Affinity DataEC50:  700nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
TargetG-protein coupled bile acid receptor 1(Human)
Wuxi Apptec (Shanghai)

Curated by ChEMBL
LigandPNGBDBM50285620(CHEMBL4164682)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/15/2020
Entry Details Article
PubMed
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