Compile Data Set for Download or QSAR
Report error Found 11 Enz. Inhib. hit(s) with all data for entry = 50002040
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataKon:  2.10E-8M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 12.5 to 200 nM by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataKon:  1.25E-7M-1s-1Assay Description:Binding affinity to recombinant human chymase assessed as dissociation constant at 6 to 1000 nM by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452609(CHEMBL4206099)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452608(CHEMBL4210939)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452612(CHEMBL4202858)
Affinity DataIC50: 78nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452605(CHEMBL4216202)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50210730(4-((R)-1-((R)-6-(5-chloro-2-methoxybenzyl)-2,5-dio...)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452610(CHEMBL4216645)
Affinity DataIC50: 570nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452606(CHEMBL4214910)
Affinity DataIC50: 580nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452607(CHEMBL4218691)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetChymase(Human)
Asubio Pharma

Curated by ChEMBL
LigandPNGBDBM50452611(CHEMBL4218983)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of recombinant human chymase pre-incubated for 10 mins before Suc-Ala-Ala-Pro-Phe-MCA substrate addition and measured after 10 mins by flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed