Compile Data Set for Download or QSAR
Report error Found 28 Enz. Inhib. hit(s) with all data for entry = 50001456
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263777(6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 0.300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263894(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 0.300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 0.700nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263894(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 3nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263777(6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263669(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 4nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263894(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 11nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263707(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263894(5-[4-[(3S)- 1-(3- fluoropropyl)- pyrrolidin-3- yl]...)
Affinity DataIC50: 18nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 27nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 29nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263688(US9714221, Example 25)
Affinity DataIC50: 38nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by in cell western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263837(6-[4- (difluoro- methoxy)-2- fluoro- phenyl]-1- fl...)
Affinity DataIC50: 47nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM50279570(CHEMBL4165845)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263777(6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 67nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263777(6-(3-fluoro- 4-methoxy- phenyl)-5- [4-[(3S)-1- (3-...)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263688(US9714221, Example 25)
Affinity DataIC50: 284nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) expressed in Escherichia coli assessed as inhibition of estrad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263688(US9714221, Example 25)
Affinity DataIC50: 728nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) Y537S mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Therachem Research Medilab (India)

Curated by ChEMBL
LigandPNGBDBM263688(US9714221, Example 25)
Affinity DataIC50: 937nMAssay Description:Antagonist activity at recombinant human His6-tagged ERalpha LBD (298 to 554 residues) D538G mutant expressed in Escherichia coli assessed as inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2020
Entry Details Article
PubMed