Compile Data Set for Download or QSAR
Report error Found 44 Enz. Inhib. hit(s) with all data for entry = 50000253
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 7nMAssay Description:Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM7266(cid_3820 | NSC 664704 | 9-bromopaullone | 14-bromo...)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50: 200nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human bFGF receptor tyrosine kinase using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human KDR using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human IGF1 receptor tyrosine kinase using biotin-GGGGKKKSPGEYVNIEFG-amide peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human insulin receptor tyrosine kinase after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human CDC2 using biotin histone H1 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CK1epsilon using biotin peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human bFGF receptor tyrosine kinase using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human bFGF receptor tyrosine kinase using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human KDR using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human KDR using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human FLT1 using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human FLT1 using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human FLT1 using KDRY1175 [B91616] biotin-GGGGQDGKDYIVLPI-NH2 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Tie2 using biotin-GGGGAPDLYKDFLT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human AKT1/PKB using phospho-AKT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human Tie2 using biotin-GGGGAPDLYKDFLT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human CK1epsilon using biotin peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human CDC2 using biotin histone H1 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CHK1 using biotin-CDC25 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCasein kinase I isoform epsilon(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CK1epsilon using biotin peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGF1 receptor tyrosine kinase using biotin-GGGGKKKSPGEYVNIEFG-amide peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDK1 using unactivated AKT substrate in presence of COPC, DOPS and PIP3 activators after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERK2 using myelin basic protein substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKCzeta using biotin-PKC-86 peptide substrate after 30 mins in the presence of phosphatidylserine and diacylglycerol activators b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AKT1/PKB using phospho-AKT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human AKT1/PKB using phospho-AKT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PKCzeta using biotin-PKC-86 peptide substrate after 30 mins in the presence of phosphatidylserine and diacylglycerol activators b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERK2 using myelin basic protein substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERK2 using myelin basic protein substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDC2 using biotin histone H1 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGF1 receptor tyrosine kinase using biotin-GGGGKKKSPGEYVNIEFG-amide peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CHK1 using biotin-CDC25 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CHK1 using biotin-CDC25 peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDK1 using unactivated AKT substrate in presence of COPC, DOPS and PIP3 activators after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human insulin receptor tyrosine kinase after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CT-98024 | N2-(2-(4-(2,4-dichlorophenyl)-5-(1H-imi...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Tie2 using biotin-GGGGAPDLYKDFLT peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed