Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50002322
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 600nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457151(CHEMBL4208328)
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457154(CHEMBL4215671)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457152(CHEMBL4203468)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457155(CHEMBL4212720)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457152(CHEMBL4203468)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457155(CHEMBL4212720)
Affinity DataIC50: 2.02E+4nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457153(CHEMBL4203992)
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457150(CHEMBL4215223)
Affinity DataIC50: 3.18E+4nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457154(CHEMBL4215671)
Affinity DataIC50: 3.41E+4nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457151(CHEMBL4208328)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457153(CHEMBL4203992)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50009859((RS)-ibuprofen | CHEMBL521 | 2-(4-isobutylphenyl)p...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50457150(CHEMBL4215223)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 5-LOX in RBL1 cells assessed as reduction in LTB4 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed