Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50001367
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277325(CHEMBL4159140)
Affinity DataEC50:  5.10E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277350(CHEMBL4167050)
Affinity DataEC50:  2.50E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277347(CHEMBL4159875)
Affinity DataEC50:  2.90E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277346(CHEMBL4163529)
Affinity DataEC50:  1.90E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277345(CHEMBL4173917)
Affinity DataEC50:  5.60E+3nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277335(CHEMBL4172495)
Affinity DataEC50:  3.10E+4nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277334(CHEMBL4170463)
Affinity DataEC50:  5.10E+3nMAssay Description:Antagonist activity at human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced receptor activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50225415(WZ-811 | N,N'-di-2-pyridinyl-1,4-benzenedimethanam...)
Affinity DataIC50: 0.300nMAssay Description:Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277349(CHEMBL4163246)
Affinity DataIC50: 1nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277344(CHEMBL4162225)
Affinity DataIC50: 8nMAssay Description:Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277326(CHEMBL4170138)
Affinity DataIC50: 8.90nMAssay Description:Binding affinity to CXCR4 in human MDA-MB-231 cells preincubated for 15 mins followed by biotinylated TN41003 addition measured after 30 mins by rhod...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277327(CHEMBL4162534)
Affinity DataIC50: 11nMAssay Description:Displacement of [125I]-SDF-1alpha from CXCR4 in human MDA-MB-231 cells after 60 mins by gamma-counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277348(CHEMBL1088913)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50035696(AMD-3100 | CHEMBL18442 | 11-{4-[4,8, 11-1,4,8,11te...)
Affinity DataIC50: 44nMAssay Description:Antagonist activity at CXCR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50155311(CHEMBL3781301)
Affinity DataIC50: 92nMAssay Description:Antagonist activity at CXCR4 in human MOLT-4 cells assessed as decrease in SDF-1alpha induced cytosolic Ca2+ levels preincubated for 30 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277328(CHEMBL4168547)
Affinity DataIC50: 120nMAssay Description:Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277337(CHEMBL4173028)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277338(CHEMBL4176412)
Affinity DataIC50: 190nMAssay Description:Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277336(CHEMBL4165124)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed
TargetC-X-C chemokine receptor type 4(Human)
University of Calabria

Curated by ChEMBL
LigandPNGBDBM50277324(CHEMBL1381819)
Affinity DataIC50: 3.80E+3nMAssay Description:Antagonist activity at CXCR4 in human U87-MG cells assessed as inhibition of CXCL12-induced cell proliferation after 1 hr by MTT assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2020
Entry Details Article
PubMed