Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50000125
TargetMu-type opioid receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240882(CHEMBL4063837)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at human mu-type opioid receptor expressed in CHO-K1 cells assessed as cAMP accumulation by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240888(CHEMBL4094256)
Affinity DataIC50: 1.10nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240884(CHEMBL4085572)
Affinity DataIC50: 5.70nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240900(CHEMBL4091620)
Affinity DataIC50: 6nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240881(CHEMBL4090712)
Affinity DataIC50: 7.5nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240885(CHEMBL4064010)
Affinity DataIC50: 12nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240882(CHEMBL4063837)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240894(CHEMBL4101988)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240883(CHEMBL4099357)
Affinity DataIC50: 13nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240890(CHEMBL4078647)
Affinity DataIC50: 14nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240887(CHEMBL4066731)
Affinity DataIC50: 18nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240886(CHEMBL4077717)
Affinity DataIC50: 27nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240879(CHEMBL4089073)
Affinity DataIC50: 46nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240878(CHEMBL4096663)
Affinity DataIC50: 48nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240893(CHEMBL4072424)
Affinity DataIC50: 94nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240876(CHEMBL4104387)
Affinity DataIC50: 101nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Rat)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240880(CHEMBL4060880)
Affinity DataIC50: 168nMAssay Description:Negative allosteric modulation of rat mGlu5 expressed in HEK293 cells assessed as inhibition of glutamate-induced intracellular calcium accumulation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240887(CHEMBL4066731)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240900(CHEMBL4091620)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240888(CHEMBL4094256)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240881(CHEMBL4090712)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240885(CHEMBL4064010)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240890(CHEMBL4078647)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240884(CHEMBL4085572)
Affinity DataKi:  5.5nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240882(CHEMBL4063837)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240879(CHEMBL4089073)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240894(CHEMBL4101988)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240889(CHEMBL4086495)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240883(CHEMBL4099357)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240886(CHEMBL4077717)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240876(CHEMBL4104387)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240878(CHEMBL4096663)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240893(CHEMBL4072424)
Affinity DataKi:  98nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50240880(CHEMBL4060880)
Affinity DataKi:  194nMAssay Description:Displacement of [3H]MPEPy from human mGlu5 expressed in HEK293FT cell membranes after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/7/2019
Entry Details Article
PubMed