Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50003226
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 in estrogen-stimulated human MCF7 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Mouse)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 48 hrs by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetHistone deacetylase(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50: 1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Rat)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468260(CHEMBL4282837)
Affinity DataIC50: 1nMAssay Description:Inhibition of rat brain PKC using RGFR derived peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 3(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468260(CHEMBL4282837)
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-tagged PAK3 (unknown origin) expressed in Escherichia coli using peptide PC9 substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Mouse)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468261(Tyrphostin Ag 879 | Tyrphostin Ag-879)
Affinity DataIC50: 5nMAssay Description:Inhibition of ETK phosphorylation in mouse RAS-3T3 cells incubated for 1 hr by immunoblotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50142887(1-tert-Butyl-3-(4-chloro-phenyl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM25116(cid_1400 | CHEMBL306380 | 1-tert-butyl-3-(4-methyl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of FYN (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50058332(methyl 10,23-di(ethylsulfanylmethyl)-16-hydroxy-15...)
Affinity DataIC50: 20nMAssay Description:Inhibition of flag-tagged MLK3 (unknown origin) expressed in human HeLa cells assessed as reduction in enzyme autophosphorylation incubated for 20 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468263(Sepantronium Bromide | YM 155 | YM-155)
Affinity DataIC50: 500nMAssay Description:Inhibition of PAK1 in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Mouse)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50058332(methyl 10,23-di(ethylsulfanylmethyl)-16-hydroxy-15...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK1 in v-Ha-RAS-transformed mouse NIH/3T3 cells incubated for 1 hr by immunoblot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468258(CHEMBL4293583)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50112354(CHEMBL472940)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468259(CHEMBL1437894)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of HA-PAK1 (unknown origin) using histone H4 substrate and [gamma-32P] ATP by autoradiographyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50468262(CHEMBL4277903)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of PAK1 in human MCF7 cells transfected with constitutively active NH2-terminally truncated C1199 Tiam1 constructMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant human COX2 expressed in baculovirus assessed as reduction in PGE2 synthesis using [3H]arachidonic acid substrate by HPLC an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM23926(5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human PAK1 by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Pak Research Center

Curated by ChEMBL
LigandPNGBDBM50362836(ARTEPILLIN)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PAK1 (unknown origin) by cell culture based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed