Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 50022562
TargetDNA topoisomerase 2-alpha(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 11nMAssay Description:Inhibition of TOP2A in human 90-8TL cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 17nMAssay Description:Inhibition of TOP2A in human ST88-14 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 26nMAssay Description:Inhibition of TOP2A in human STS26T cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 41nMAssay Description:Inhibition of TOP2A in human T265 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM22984(Adriamycin | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5...)
Affinity DataIC50: 124nMAssay Description:Inhibition of TOP2A in human SNF96.2 cells assessed as reduction in cell viability at 1 to 500 ng/ml incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Mouse)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 400nMAssay Description:Inhibition of BRD4 in mouse MPNST cells assessed as reduction in cell viability incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Mouse)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 400nMAssay Description:Inhibition of BRD4 in mouse primary skin-derived precursors (Nf1-/-, P53-/-) assessed as reduction in cell viability incubated for 72 hrs by SRB assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of BRD4 in human SNF96.2 cells assessed as reduction in cell viability at 4.9 to 2500 nM incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of BRD4 in human T265 cells assessed as reduction in cell viability at 4.9 to 2500 nM incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Erasmus University Medical Center

Curated by ChEMBL
LigandPNGBDBM50365262(CHEMBL1957266 | (S)-JQ1 (1) | US9320741, (S)-JQ1 |...)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of BRD4 in human 90-8TL cells assessed as reduction in cell viability at 4.9 to 2500 nM incubated for 72 hrs by SRB assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed